EXPRESSION OF CYTOCHROME-P450 CYP1B1 IN BREAST-CANCER

被引：115

作者：

MCKAY, JA

MELVIN, WT

AHSEE, AK

EWEN, SWB

GREENLEE, WF

MARCUS, CB

BURKE, MD

MURRAY, GI

机构：

[1] UNIV ABERDEEN,DEPT PATHOL,ABERDEEN AB9 2ZD,SCOTLAND

[2] UNIV ABERDEEN,DEPT MOLEC & CELL BIOL,ABERDEEN AB9 2ZD,SCOTLAND

[3] UNIV ABERDEEN,DEPT SURG,ABERDEEN AB9 2ZD,SCOTLAND

[4] UNIV ABERDEEN,DEPT BIOMED SCI,ABERDEEN AB9 2ZD,SCOTLAND

[5] PURDUE UNIV,DEPT PHARMACOL & TOXICOL,W LAFAYETTE,IN 47907

来源：

FEBS LETTERS | 1995年 / 374卷 / 02期

关键词：

BREAST; CANCER; CYTOCHROME P450; NEOPLASM;

D O I：

10.1016/0014-5793(95)01126-Y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The expression of CYP1B1 has been identified in breast cancer using the reverse transcriptase-polymerase chain reaction and immunoblotting, CYP1B1 mRNA was expressed in the majority of breast tumours and immunoblotting of breast tumours identified a single protein band of molecular weight 60 kDa corresponding to the predicted molecular weight of human CYP1B1. This is the first study to identify CYP1B1 expression in a tumour where it may represent a previously unknown pathway for the metabolism of oestradiol and chemotherapeutic drugs.

引用

页码：270 / 272

页数：3

共 20 条

[1] CYTOCHROME-P450 AND THE ARACHIDONATE CASCADE
CAPDEVILA, JH
FALCK, JR
ESTABROOK, RW
[J]. FASEB JOURNAL, 1992, 6 (02) : 731 - 736
[2] CHOMCZYNSKI P, 1987, ANAL BIOCHEM, V162, P156, DOI 10.1016/0003-2697(87)90021-2
[3] PREVENTION OF PRE-PCR MIS-PRIMING AND PRIMER DIMERIZATION IMPROVES LOW-COPY-NUMBER AMPLIFICATIONS
CHOU, Q
RUSSELL, M
BIRCH, DE
RAYMOND, J
BLOCH, W
[J]. NUCLEIC ACIDS RESEARCH, 1992, 20 (07) : 1717 - 1723
[4] REGULATION OF CYP1A1 EXPRESSION
FUJIIKURIYAMA, Y
IMATAKA, H
SOGAWA, K
YASUMOTO, KI
KIKUCHI, Y
[J]. FASEB JOURNAL, 1992, 6 (02) : 706 - 710
[5] ROLE OF HUMAN CYTOCHROMES P450 IN THE METABOLIC-ACTIVATION OF CHEMICAL CARCINOGENS AND TOXINS
GONZALEZ, FJ
GELBOIN, HV
[J]. DRUG METABOLISM REVIEWS, 1994, 26 (1-2) : 165 - 183
[6] HUMAN P3450 - CDNA AND COMPLETE AMINO-ACID-SEQUENCE
JAISWAL, AK
NEBERT, DW
GONZALEZ, FJ
[J]. NUCLEIC ACIDS RESEARCH, 1986, 14 (16) : 6773 - 6774
[7] HUMAN DIOXIN-INDUCIBLE CYTOCHROME-P1-450 - COMPLEMENTARY-DNA AND AMINO-ACID SEQUENCE
JAISWAL, AK
GONZALEZ, FJ
NEBERT, DW
[J]. SCIENCE, 1985, 228 (4695) : 80 - 83
[8] LOCALIZATION OF MICROSOMAL EPOXIDE HYDROLASE IN NORMAL AND NEOPLASTIC HUMAN KIDNEY
MCKAY, JA
WEAVER, RJ
MURRAY, GI
EWEN, SWB
MELVIN, WT
BURKE, MD
[J]. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 1995, 43 (06) : 615 - 620
[9] MOLECULAR-BIOLOGY OF STEROID-HORMONE SYNTHESIS
MILLER, WL
[J]. ENDOCRINE REVIEWS, 1988, 9 (03) : 295 - 318
[10] EXPRESSION OF CYTOCHROME-P450IA IN BREAST-CANCER
MURRAY, GI
FOSTER, CO
BARNES, TS
WEAVER, RJ
EWEN, SWB
MELVIN, WT
BURKE, MD
[J]. BRITISH JOURNAL OF CANCER, 1991, 63 (06) : 1021 - 1023

← 1 2 →