Sequential chemoimmunotherapy for advanced non-small cell lung cancer using cisplatin, etoposide, thymosin-alpha 1 and interferon-alpha 2a

被引：34

作者：

Garaci, E

Lopez, M

Bonsignore, G

DellaGiulia, M

DAprile, M

Favalli, C

Rasi, G

Santini, S

Capomolla, E

Vici, P

DiLauro, L

机构：

[1] REGINA ELENA INST CANC RES,I-00161 ROME,ITALY

[2] UNIV ROMA TOR VERGATA,ROME,ITALY

[3] UNIV PALERMO,PNEUMOL INST,PALERMO,ITALY

[4] CTR ONCOL,LATINA,ITALY

[5] IRCCS,ROME,ITALY

来源：

EUROPEAN JOURNAL OF CANCER | 1995年 / 31A卷 / 13-14期

关键词：

thymosin-alpha; 1; chemotherapy; NSCLC; interferon-alpha; 2a;

D O I：

10.1016/0959-8049(95)00477-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A phase II study was performed to evaluate the clinical and immunological effects of a regimen of cisplatin (DDP) and etoposide (VP-16) combined with thymosin-alpha 1 (TA1) and low-dose interferon-alpha 2a (IFN) in the treatment of patients with advanced non-small cell lung cancer (NSCLC). Chemoimmunotherapy cycles were repeated every 3 weeks. There were 24 responses (two complete, 22 partial) among 56 assessable patients. Median survival was 12.6 months. Overall, treatment was well tolerated. Natural killer cell activity and lymphocyte subtypes were depressed by chemotherapy, but this effect was less prominent in patients receiving TA1 and IFN in comparison with a concomitant group of patients treated with DDP and VP-16 only. The combination of DDP and VP-16 and TA1 and IFN is effective in advanced NSCLC with acceptable toxicity. However, the results of this study need to be confirmed in a randomised trial.

引用

页码：2403 / 2405

页数：3

共 16 条

[11]

MILLER AB, 1981, CANCER, V47, P207, DOI 10.1002/1097-0142(19810101)47:1<207::AID-CNCR2820470134>3.0.CO

[12]

2-6

[13]

OATES KK, 1991, BIOL THERAPY CANCER, P705

[14] RANDOMIZED PHASE II-III TRIAL OF COMBINATION BETA-INTERFERON AND GAMMA-INTERFERON AND ETOPOSIDE AND CISPLATIN IN INOPERABLE NON-SMALL CELL-CANCER OF THE LUNG [J].

SCHILLER, JH ;

STORER, B ;

DREICER, R ;

ROSENQUIST, D ;

FRONTIERA, M ;

CARBONE, PP .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1989, 81 (22) :1739-1743

[15] A RANDOMIZED TRIAL OF 5 CISPLATIN-CONTAINING TREATMENTS IN PATIENTS WITH METASTATIC NON-SMALL-CELL LUNG-CANCER - A SOUTHWEST-ONCOLOGY-GROUP-STUDY [J].

WEICK, JK ;

CROWLEY, J ;

NATALE, RB ;

HOM, BL ;

RIVKIN, S ;

COLTMAN, CA ;

TAYLOR, SA ;

LIVINGSTON, RB .

JOURNAL OF CLINICAL ONCOLOGY, 1991, 9 (07) :1157-1162

[16]

WEISSLER JC, 1987, AM REV RESPIR DIS, V135, P1353

← 1 2 →