A POTENTIAL NONINVASIVE NEUROBIOLOGICAL TEST FOR ALZHEIMERS-DISEASE

被引：180

作者：

SCINTO, LFM

DAFFNER, KR

DRESSLER, D

RANSIL, BI

RENTZ, D

WEINTRAUB, S

MESULAM, M

POTTER, H

机构：

[1] HARVARD UNIV,SCH MED,DEPT NEUROBIOL,BOSTON,MA 02115

[2] BETH ISRAEL HOSP,BOSTON,MA 02215

[3] NORTHWESTERN UNIV,SCH MED,CTR COGNIT & BEHAV NEUROL,CHICAGO,IL 60611

来源：

SCIENCE | 1994年 / 266卷 / 5187期

关键词：

D O I：

10.1126/science.7973660

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Currently Alzheimer's disease, which affects more than 20 million people worldwide, can only be definitively diagnosed by histological examination of brain tissue obtained at autopsy or biopsy. There is a great need for an early, noninvasive, sensitive, and easily administered diagnostic test of Alzheimer's disease. Here it is reported that patients diagnosed with probable Alzheimer's disease by standard clinical criteria exhibited a marked hypersensitivity in their pupil dilation response to a cholinergic antagonist, tropicamide, placed in their eyes. It was possible to distinguish 18 of 19 individuals (95%) either clinically diagnosed with Alzheimer's disease or classified as suspect Alzheimer's individuals by neuropsychological screening from 30 of 32 normal elderly controls (94%).

引用

页码：1051 / 1054

页数：4

共 26 条

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[2]

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