SYNTHESIS, ANTIFUNGAL AND NEMATOCIDAL ACTIVITIES OF THIOUREINES WITH AN AMINOESTER SEQUENCE

被引：5

作者：

CAUJOLLE, R

AMAROUCH, H

PAYARD, M

LOISEAU, PM

BORIES, C

GAYRAL, P

LINAS, MD

SEGUELA, JP

机构：

[1] FAC SCI CASABLANCA,DEPT BIOL,CASABLANCA,MOROCCO

[2] FAC PHARM CHATENAY MALABRY,PARASITOL LAB,F-92290 CHATENAY MALABRY,FRANCE

[3] CHU RANGUEIL,PARASITOL & MYCOL LAB,F-31054 TOULOUSE,FRANCE

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1995年 / 30卷 / 10期

关键词：

ANTIFUNGAL ACTIVITY; ANTHELMINTIC; THIOUREINE;

D O I：

10.1016/0223-5234(96)88299-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Twenty-three arylthioureines bearing beta-alanine or gamma-aminobutyric alkyl ester chains were synthesized for in vitro screening toward 44 strains of fungi and 2 genera of nematodes. The nitro derivatives were the most potent compounds against Aspergillus and Candida strains. Ester chains increase activity against the filarial worm Molinema dessetae. Twelve compounds have EC(50) < 40 mu g/ml. However, the anthelmintic potency is weak compared with tetramisole.

引用

页码：801 / 807

页数：7

共 16 条

[1] PHARMACOLOGY OF IVERMECTIN [J].