PHARMACODYNAMIC INTERACTION BETWEEN MIDAZOLAM AND A LOW-DOSE OF ETHANOL IN-VIVO

被引：11

作者：

HOYOVADILLO, C ^{[1
]}

MANDEMA, JW ^{[1
]}

DANHOF, M ^{[1
]}

机构：

[1] LEIDEN UNIV,LEIDEN AMSTERDAM CTR DRUG RES,DIV PHARMACOL,2300 RA LEIDEN,NETHERLANDS

来源：

LIFE SCIENCES | 1995年 / 57卷 / 04期

关键词：

ETHANOL; MIDAZOLAM; PHARMACODYNAMIC INTERACTIONS;

D O I：

10.1016/0024-3205(95)00291-D

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The pharmacokinetic and pharmacodynamic interactions between midazolam and ethanol were studied in the rat in vivo. Ethanol was given as a constant rate intravenous infusion (1.85 mg/min). The pharmacokinetics and pharmacodynamics of midazolam were determined following an intravenous dose of 5 mg/kg in 15 minutes. Amplitudes in the 11.5-30 Hz (beta) frequency band of the EEG was used as a measure of the pharmacological effect. Ethanol infusion resulted in a constant plasma alcohol concentration of 0.44 +/- 0.04 g/l (Mean +/- SE) and had no effect on the baseline value of the EEG effect parameter. Also the pharmacokinetics of midazolam were unchanged. However, a significant parallel shift of the midazolam concentration-EEG effect relationship to lower concentrations was observed. These findings show that there is a pharmacodynamic interaction between midazolam and ethanol in vivo.

引用

页码：325 / 333

页数：9

共 28 条

[11]

Van Steveninck, Gieschke, Schoemaker, Pieters, Kroon, Breimer, Cohen, Psychopharmacol., 110, pp. 471-478, (1993)

[12]

Mandema, Tukker, Danhof, Br. J. Pharmacol., 102, pp. 663-668, (1991)

[13]

Mandema, Sansom, Dios-Vieitez, Hollander-Jansen, Danhof, J. Pharmacol. Exp. Ther., 257, pp. 472-478

[14]

Mandema, Kuck, Danhof, Br. J. Pharmacol., 105, pp. 164-170, (1992)

[15]

Mandema, Tukker, Danhof, J. Pharmacol. Exp. Ther., 260, pp. 36-44, (1992)

[16]

Mandema, Kuck, Danhof, J. Pharmacol. Exp. Ther., 261, pp. 56-61, (1992)

[17]

Breimer, Hennis, Burm, Danhof, Bovill, Vletter, De Voogt, Clin. Pharmacokin., 20, pp. 491-496, (1991)

[18]

Mandema, Danhof, J. Pharmacokin. Biopharm., 18, pp. 459-481, (1990)

[19]

Gregory, Pettus, J. Clin. Monit., 2, pp. 190-197, (1986)

[20]

Gibaldi, Perrier, Pharmacokinetics, pp. 409-424, (1982)

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