PHARMACODYNAMIC INTERACTION BETWEEN MIDAZOLAM AND A LOW-DOSE OF ETHANOL IN-VIVO

被引:11
作者
HOYOVADILLO, C [1 ]
MANDEMA, JW [1 ]
DANHOF, M [1 ]
机构
[1] LEIDEN UNIV,LEIDEN AMSTERDAM CTR DRUG RES,DIV PHARMACOL,2300 RA LEIDEN,NETHERLANDS
关键词
ETHANOL; MIDAZOLAM; PHARMACODYNAMIC INTERACTIONS;
D O I
10.1016/0024-3205(95)00291-D
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
The pharmacokinetic and pharmacodynamic interactions between midazolam and ethanol were studied in the rat in vivo. Ethanol was given as a constant rate intravenous infusion (1.85 mg/min). The pharmacokinetics and pharmacodynamics of midazolam were determined following an intravenous dose of 5 mg/kg in 15 minutes. Amplitudes in the 11.5-30 Hz (beta) frequency band of the EEG was used as a measure of the pharmacological effect. Ethanol infusion resulted in a constant plasma alcohol concentration of 0.44 +/- 0.04 g/l (Mean +/- SE) and had no effect on the baseline value of the EEG effect parameter. Also the pharmacokinetics of midazolam were unchanged. However, a significant parallel shift of the midazolam concentration-EEG effect relationship to lower concentrations was observed. These findings show that there is a pharmacodynamic interaction between midazolam and ethanol in vivo.
引用
收藏
页码:325 / 333
页数:9
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