NEW FUNCTIONS FOR GAP-JUNCTIONS

被引：174

作者：

PAUL, DL

机构：

[1] Department of Neurobiology, Harvard Medical School, Boston, MA 02115

来源：

CURRENT OPINION IN CELL BIOLOGY | 1995年 / 7卷 / 05期

关键词：

D O I：

10.1016/0955-0674(95)80108-1

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The most significant finding of the past year in gap junction research has been the association of connexin defects with human diseases. Connexin32 mutations cause X-linked Charcot-Marie-Tooth disease, a demyelinating peripheral neuropathy. Mutations in connexin43 may underlie cardiac malformations in visceroatrial heterotaxia syndromes. Genetic approaches and gene targeting have provided new insights, but also raise new questions concerning connexin function, the significance of connexin diversity and the regulation of intercellular communication.

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收藏

页码：665 / 672

页数：8

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