A COMPARISON OF THE EXTRUSION AND SPHERONIZATION BEHAVIOR OF WET POWDER MASSES PROCESSED BY A RAM EXTRUDER AND A CYLINDER EXTRUDER

被引：31

作者：

FIELDEN, KE

NEWTON, JM

ROWE, RC

机构：

[1] UNIV LONDON,SCH PHARM,29-39 BRUNSWICK SQ,LONDON WC1N 1AX,ENGLAND

[2] WELLCOME FDN LTD,DARTFORD DA1 5AH,KENT,ENGLAND

[3] ICI PLC,PHARMACEUT,MACCLESFIELD SK10 4TG,CHESHIRE,ENGLAND

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1992年 / 81卷 / 2-3期

关键词：

EXTRUSION SPHERONIZATION; MICROCRYSTALLINE CELLULOSE; PARTICLE SIZE EFFECT; LACTOSE; RAM EXTRUDER; CYLINDER EXTRUDER; DIE DIAMETER; SPHERICAL GRANULE;

D O I：

10.1016/0378-5173(92)90014-S

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The preparation of spherical granules by spheronization of extrudate obtained by extrusion through either a cylinder or ram extruder of a mixture of microcrystalline cellulose, lactose (with median diameter of either 18 or 117-mu-m) and water has been undertaken. Spheroids of a uniform size and shape could be produced from both particle size ranges of lactose if the cylinder extruder was used but not if the ram extruder formed the extrudate. The differences appear to be associated with the different rates of shear and the shear stresses involved in the two extrusion processes.

引用

页码：225 / 233

页数：9

共 11 条

[1]

ANDERSEN AH, 1990, RHEOLOGY OF FOOD, PHARMACEUTICAL AND BIOLOGICAL MATERIALS WITH GENERAL RHEOLOGY, P258

[2] THE INFLUENCE OF MOISTURE-CONTENT ON THE PREPARATION OF SPHERICAL GRANULES OF BARIUM-SULFATE AND MICROCRYSTALLINE CELLULOSE [J].