RIBOSOMAL FRAMESHIFTING IN YEAST VIRUSES

被引：62

作者：

DINMAN, JD ^{[1
]}

机构：

[1] NIDDKD, BIOCHEM PHARMACOL LAB, GENET SIMPLE EUKARYOTES SECT, BETHESDA, MD 20892 USA

来源：

YEAST | 1995年 / 11卷 / 12期

关键词：

SACCHAROMYCES CEREVISIAE; RIBOSOMES; RIBOSOMAL FRAMESHIFTING; L-A DSRNA VIRUS; TY; RETROTRANSPOSON; RETROVIRUS; HUNGRY CODONS; POLYAMINES;

D O I：

10.1002/yea.320111202

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Proper maintenance of translational reading frame by ribosomes is essential for cell growth and viability. In the last 10 years it has been shown that a number of viruses induce ribosomes to shift reading frame in order to regulate the expression of gene products having enzymatic functions. Studies on ribosomal frameshifting in viruses of yeast have been particularly enlightening. The roles of viral mRNA sequences and secondary structures have been elucidated and a picture of how these interact with host chromosomal gene products is beginning to emerge. The efficiency of ribosomal frameshifting is important for viral particle assembly, and has identified ribosomal frameshifting as a potential target for antiviral agents. The availability of mutants of host chromosomal gene products involved in maintaining the efficiency of ribosomal frameshifting bodes well for the use of yeast in future studies of ribosomal frameshifting.

引用

页码：1115 / 1127

页数：13

共 60 条

[11] VIRUS-LIKE PARTICLES OF YEAST [J].

BRUENN, JA .

ANNUAL REVIEW OF MICROBIOLOGY, 1980, 34 :49-68

[12] K1 KILLER TOXIN, A PORE-FORMING PROTEIN FROM YEAST [J].

BUSSEY, H .

MOLECULAR MICROBIOLOGY, 1991, 5 (10) :2339-2343

[13] TRANSLATIONAL FRAMESHIFTING IN THE CONTROL OF TRANSPOSITION IN BACTERIA [J].

CHANDLER, M ;

FAYET, O .

MOLECULAR MICROBIOLOGY, 1993, 7 (04) :497-503

[14] FUNGAL VIRUS CAPSIDS, CYTOPLASMIC COMPARTMENTS FOR THE REPLICATION OF DOUBLE-STRANDED-RNA, FORMED AS ICOSAHEDRAL SHELLS OF ASYMMETRIC GAG DIMERS [J].

CHENG, RH ;

CASTON, JR ;

WANG, GJ ;

GU, F ;

SMITH, TJ ;

BAKER, TS ;

BOZARTH, RF ;

TRUS, BL ;

CHENG, NQ ;

WICKNER, RB ;

STEVEN, AC .

JOURNAL OF MOLECULAR BIOLOGY, 1994, 244 (03) :255-258

[15] NUCLEOTIDE-SEQUENCE OF A YEAST TY ELEMENT - EVIDENCE FOR AN UNUSUAL MECHANISM OF GENE-EXPRESSION [J].

CLARE, J ;

FARABAUGH, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (09) :2829-2833

[16] IDENTIFICATION AND CHARACTERIZATION OF GENES THAT ARE REQUIRED FOR THE ACCELERATED DEGRADATION OF MESSENGER-RNAS CONTAINING A PREMATURE TRANSLATIONAL TERMINATION CODON [J].

CUI, Y ;

HAGAN, KW ;

ZHANG, SA ;

PELTZ, SW .

GENES & DEVELOPMENT, 1995, 9 (04) :423-436

[17]

CUI Y, 1995, UNP0UB P NATL ACAD S

[18] RIBOSOMAL FRAMESHIFTING EFFICIENCY AND GAG GAG-POL RATIO ARE CRITICAL FOR YEAST M(1) DOUBLE-STRANDED-RNA VIRUS PROPAGATION [J].

DINMAN, JD ;

WICKNER, RB .

JOURNAL OF VIROLOGY, 1992, 66 (06) :3669-3676

[19] A -1 RIBOSOMAL FRAMESHIFT IN A DOUBLE-STRANDED-RNA VIRUS OF YEAST FORMS A GAG POL FUSION PROTEIN [J].

DINMAN, JD ;

ICHO, T ;

WICKNER, RB .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (01) :174-178

[20]

DINMAN JD, 1994, GENETICS, V136, P75

← 1 2 3 4 5 6 →