EFFICIENT SYNTHESIS OF METHYL 2-(TERT-BUTYL)ACRYLATE AND ANALOGOUS ESTERS

被引：19

作者：

XU, LH ^{[1
]}

KUNDIG, EP ^{[1
]}

机构：

[1] UNIV GENEVA,DEPT CHIM ORGAN,CH-1211 GENEVA 4,SWITZERLAND

来源：

HELVETICA CHIMICA ACTA | 1994年 / 77卷 / 06期

关键词：

D O I：

10.1002/hlca.19940770603

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The title products are prepared via an efficient three-step synthesis which involves hydroalumination of methyl propiolate and Lewis-acid-promoted reaction with acetone in the presence of BF3 followed by two highly selective S(N)2' reactions. The key step is the reaction of 2-(chloromethyl)acrylates with R(2)CuLi/ZnCl2 reagents which takes place with complete allylic rearrangement.

引用

页码：1480 / 1484

页数：5

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