THYMUS INVOLUTION INDUCED BY MOUSE HEPATITIS-VIRUS A59 IN BALB/C MICE

被引:50
作者
GODFRAIND, C
HOLMES, KV
COUTELIER, JP
机构
[1] UNIV CATHOLIQUE LOUVAIN,ICP,UNIT EXPTL MED,B-1200 BRUSSELS,BELGIUM
[2] UNIV CATHOLIQUE LOUVAIN,HOP ST LUC,PATHOL LAB,B-1200 BRUSSELS,BELGIUM
[3] UNIV CATHOLIQUE LOUVAIN,EXPTL MED UNIT,B-1200 BRUSSELS,BELGIUM
[4] INT INST CELLULAR & MOLEC PATHOL,B-1200 BRUSSELS,BELGIUM
[5] UNIFORMED SERV UNIV HLTH SCI,DEPT PATHOL,BETHESDA,MD 20814
关键词
D O I
10.1128/JVI.69.10.6541-6547.1995
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Mouse hepatitis virus A59 (MHV-A59) infection of adult BALB/c mice induced a severe, transient atrophy of the thymus. The effect was maximal at 1 week after infection, and thymuses returned to normal size by 2 weeks after infection. There was no effect of glucocorticoids, since thymus atrophy was also found in adrenalectomized, infected mice. In infected thymus, immature CD4(+) CD8(+) lymphocytes were selectively depleted, and apoptosis of lymphocytes was increased. The MHV receptor glycoprotein MHVR was detected on thymus epithelial cells but not on T lymphocytes. In a small number of stromal epithelial cells, but in very few lymphocytes, the viral genome was detectable by in situ hybridization. These observations suggested that MHV-A59-induced thymic atrophy results not from a generalized lytic infection of T lymphocytes but rather from apoptosis of immature double-positive T cells that might be caused by infection of a small proportion of thymus epithelial cells or from inappropriate secretion of some factor, such as a cytokine.
引用
收藏
页码:6541 / 6547
页数:7
相关论文
共 66 条
  • [61] VIRELIZIER JL, 1976, J IMMUNOL, V117, P748
  • [62] TRANSFORMING GROWTH FACTOR-BETA(2) INDUCES APOPTOSIS OF MURINE T-CELL CLONES WITHOUT DOWN-REGULATING BCL-2 MESSENGER-RNA EXPRESSION
    WELLER, M
    CONSTAM, DB
    MALIPIERO, U
    FONTANA, A
    [J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 1994, 24 (06) : 1293 - 1300
  • [63] A NEW METHOD TO DETECT APOPTOSIS IN PARAFFIN SECTIONS - INSITU END-LABELING OF FRAGMENTED DNA
    WIJSMAN, JH
    JONKER, RR
    KEIJZER, R
    VANDEVELDE, CJH
    CORNELISSE, CJ
    VANDIERENDONCK, JH
    [J]. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 1993, 41 (01) : 7 - 12
  • [64] PURIFICATION OF THE 110-KILODALTON GLYCOPROTEIN RECEPTOR FOR MOUSE HEPATITIS-VIRUS (MHV)-A59 FROM MOUSE-LIVER AND IDENTIFICATION OF A NONFUNCTIONAL, HOMOLOGOUS PROTEIN IN MHV-RESISTANT SJL/J MICE
    WILLIAMS, RK
    JIANG, GS
    SNYDER, SW
    FRANA, MF
    HOLMES, KV
    [J]. JOURNAL OF VIROLOGY, 1990, 64 (08) : 3817 - 3823
  • [65] RECEPTOR FOR MOUSE HEPATITIS-VIRUS IS A MEMBER OF THE CARCINOEMBRYONIC ANTIGEN FAMILY OF GLYCOPROTEINS
    WILLIAMS, RK
    JIANG, GS
    HOLMES, KV
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (13) : 5533 - 5536
  • [66] MOUSE HEPATITIS-VIRUS UTILIZES 2 CARCINOEMBRYONIC ANTIGENS AS ALTERNATIVE RECEPTORS
    YOKOMORI, K
    LAI, MMC
    [J]. JOURNAL OF VIROLOGY, 1992, 66 (10) : 6194 - 6199