EXPRESSION OF C-FOS PROTEIN BY N-METHYL-D-ASPARTIC ACID IN HYPOTHALAMUS OF IMMATURE FEMALE RATS - BLOCKADE BY MK-801 OR NEONATAL TREATMENT WITH MONOSODIUM GLUTAMATE

被引：32

作者：

MACDONALD, MC

ROBERTSON, HA

WILKINSON, M

机构：

[1] DALHOUSIE UNIV,FAC MED,DEPT OBSTET & GYNECOL,ROOM 5H1,SIR CHARLES TUPPER MED BLDG,HALIFAX B3H 4H7,NS,CANADA

[2] DALHOUSIE UNIV,DEPT PHARMACOL,HALIFAX B3H 4H7,NS,CANADA

[3] DALHOUSIE UNIV,DEPT PHYSIOL & BIOPHYS,HALIFAX B3H 4H7,NS,CANADA

来源：

DEVELOPMENTAL BRAIN RESEARCH | 1990年 / 56卷 / 02期

关键词：

2-Amino-5-phosphonovalerate; Arcuate nucleus; MK-801; Monosodium glutamate; N-Methyl-d-aspartic acid;

D O I：

10.1016/0165-3806(90)90096-H

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Significant NMDA-induced cellular activity in the median eminence-arcuate region of immature female rats was immunocytochemically localized via c-fos protein-like immunoreactivity. The production of this protein was completely prevented by pre-injection of MK-801 or APV, antagonists of the NMDA receptor-coupled ion channel. Treatment of newborn rats with monosodium glutamate (MSG), which destroys glutamate-sensitive neurons, significantly attenuated NMDA-induced c-fos when tested in the peripubertal period. These results implicate NMDA receptors in the expression of c-fos protein-like immunoreactivity in cells of the arcuate nucleus-median eminence of immature female rats. © 1990.

引用

页码：294 / 297

页数：4

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