ACYLOXY-TRI(ISOPROPOXY)TITANIUM REAGENTS FOR REGIOSELECTIVE CLEAVAGE OF 2,3-EPOXYALCOHOLS - A SYNTHESIS OF 2-DEOXY-D-RIBOSE

被引：13

作者：

RAIFELD, YE

NIKITENKO, A

ARSHAVA, BM

机构：

[1] Joint Laboratory of Carbohydrates and Nucleoside Synthesis, Moscow, 117571, Moscow Institute Fine Chemical Technology and JV Angarex Vernadsky Ave.

来源：

TETRAHEDRON | 1993年 / 49卷 / 12期

关键词：

D O I：

10.1016/S0040-4020(01)86329-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The cleavage of the oxirane ring of 3,4-anhydro-2-deoxy-D-threo-pentose diethyl acetal by various acetic acid derivatives - titanium(IV) isopropoxide combinations are reported in detail. The high regioselectivity found with tri(isopropoxy)titanium acetate serves as the basis for a synthesis of 2-deoxy-D-ribose and its ethyl furanosides in high yields and optical purity from non-carbohydrate precursors. The synthesis of other acyloxy tri(isopropoxy)titanium reagents is also described.

引用

页码：2509 / 2514

页数：6

共 12 条

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