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RAT-HEART FATTY-ACID-BINDING PROTEIN-CONTENT IS INCREASED IN EXPERIMENTAL DIABETES

被引：50
作者：
GLATZ, JFC
VANBREDA, E
KEIZER, HA
DEJONG, YF
LAKEY, JRT
RAJOTTE, RV
THOMPSON, A
VANDERVUSSE, GJ
LOPASCHUK, GD
机构：
[1] UNIV LIMBURG,DEPT MOT SCI,6200 MD MAASTRICHT,NETHERLANDS
[2] UNIV ALBERTA,FAC MED,SURG MED RES INST,EDMONTON,AB,CANADA
[3] UNIV ALBERTA,FAC MED,CARDIOVASC DIS RES GRP,EDMONTON,AB,CANADA
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 199卷 / 02期
关键词：
D O I：
10.1006/bbrc.1994.1276
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cytoplasmic fatty acid-binding protein (FABP) was assayed immunochemically in hearts from rats with insulin-dependent (IDDM) or non-insulin-dependent diabetes mellitus (NIDDM). FABP contents were 34% higher in IDDM and 103% higher in NIDDM hearts than in respective age-matched controls. FABP levels returned to control values when islets of Langerhans were transplanted into diabetic IDDM animals. In the diabetic hearts the activity of fructose-6-phosphate kinase decreased (IDDM and NIDDM animals), while that of 3-hydroxyacyl-CoA dehydrogenase increased (NIDDM animals only). These data indicate that experimental diabetes induces a marked increase of the FABP content of rat heart and suggests that this protein is involved in the enhanced fatty acid utilization by the diabetic heart. (C) 1994 Academic Press, Inc.
引用
收藏
页码：639 / 646
页数：8
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