THE CHART TRIALS - BAYESIAN DESIGN AND MONITORING IN PRACTICE

被引：77

作者：

PARMAR, MKB

SPIEGELHALTER, DJ

FREEDMAN, LS

机构：

[1] UNIV CAMBRIDGE,MRC,INST PUBL HLTH,BIOSTAT UNIT,CAMBRIDGE CB2 2SR,ENGLAND

[2] NCI,DIV CANC PREVENT & CONTROL,BIOMETRY BRANCH,BETHESDA,MD 20892

来源：

STATISTICS IN MEDICINE | 1994年 / 13卷 / 13-14期

关键词：

D O I：

10.1002/sim.4780131304

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In this paper we describe the design and monitoring of two large randomized trials being conducted through the British Medical Research Council (MRC) Cancer Trials Office. In particular we discuss the issues involved in the design of the trials, specifying the null and alternative hypotheses and how the design has influenced the monitoring procedure used. From these two examples, and some other MRC experiences, we suggest some basic considerations which could be applied to many MRC and other trials.

引用

页码：1297 / 1312

页数：16

共 17 条

[1] THE WHAT, WHY AND HOW OF BAYESIAN CLINICAL-TRIALS MONITORING [J].