THE HYPOGLYCEMIC ACTIVITY OF SWERTIA-JAPONICA EXTRACT IN STREPTOZOTOCIN-INDUCED HYPERGLYCEMIC RATS

被引：13

作者：

BASNET, P

KADOTA, S

NAMBA, T

SHIMIZU, M

机构：

[1] TOYAMA MED & PHARMACEUT UNIV, WAKAN YAKU RES INST, TOYAMA 93001, JAPAN

[2] TOYAMA MED & PHARMACEUT UNIV, FAC PHARMACEUT SCI, TOYAMA 93001, JAPAN

来源：

PHYTOTHERAPY RESEARCH | 1994年 / 8卷 / 01期

关键词：

SWERTIA JAPONICA EXTRACT; FRACTIONATION; BLOOD GLUCOSE LEVELS; STREPTOZOTOCIN INDUCED HYPERGLYCEMIA; RATS;

D O I：

10.1002/ptr.2650080114

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The hypoglycaemic activity of an aqueous ethanolic extract of Swertia japonica and its ethyl acetate, n-butanol, water soluble fractions, together with ether soluble and insoluble fractions of ethyl acetate soluble fraction was observed in streptozotocin (STZ) induced hyperglycaemic rats. It was found that an aqueous ethanolic extract was more effective than a mixture of tolbutamide and buformine, and an ethanolic extract of another species of this plant, S. chirayita in lowering the blood glucose level under similar experimental conditions. Furthermore, an ethyl acetate soluble fraction of S. japonica and its ether insoluble fraction showed a potent hypoglycaemic activity.

引用

页码：55 / 57

页数：3

共 10 条

[1] HYPOGLYCEMIC EFFECT OF SWERCHIRIN FROM THE HEXANE FRACTION OF SWERTIA-CHIRAYITA [J].