LEUHISTIN, A NEW INHIBITOR OF AMINOPEPTIDASE-M, PRODUCED BY BACILLUS-LATEROSPORUS BMI156-14F1 .2. STRUCTURE DETERMINATION OF LEUHISTIN

被引：10

作者：

YOSHIDA, S ^{[1
]}

NAGANAWA, H ^{[1
]}

AOYAGI, T ^{[1
]}

TAKEUCHI, T ^{[1
]}

TAKEUCHI, Y ^{[1
]}

KODAMA, Y ^{[1
]}

机构：

[1] MEIJI SEIKA KAISHA LTD,PHARMACEUT RES CTR,KOUHOKU KU,YOKOHAMA 222,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1991年 / 44卷 / 06期

关键词：

D O I：

10.7164/antibiotics.44.579

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Leuhistin, a new inhibitor of aminopeptidase M, has been isolated from the culture broth of Bacillus laterosporus BMI156-14F1. The structure of leuhistin was determined by NMR studies. X-Ray and chemical analysis confirmed the absolute structure to be (2R,3S)-3-amino-2-hydroxy-2-(1H-imidazol-4-ylmethyl)-5-methylhexanoic acid.

引用

页码：579 / 581

页数：3

共 4 条

[1] LEUHISTIN, A NEW INHIBITOR OF AMINOPEPTIDASE-M, PRODUCED BY BACILLUS-LATEROSPORUS BMI156-14F1 .1. TAXONOMY, PRODUCTION, ISOLATION, PHYSICOCHEMICAL PROPERTIES AND BIOLOGICAL-ACTIVITIES
AOYAGI, T
YOSHIDA, S
MATSUDA, N
IKEDA, T
HAMADA, M
TAKEUCHI, T
[J]. JOURNAL OF ANTIBIOTICS, 1991, 44 (06) : 573 - 578
[2] MITHRIL - AN INTEGRATED DIRECT-METHODS COMPUTER-PROGRAM
GILMORE, CJ
[J]. JOURNAL OF APPLIED CRYSTALLOGRAPHY, 1984, 17 (FEB) : 42 - 46
[3] HULL SE, 1971, ACTA CRYSTALLOGR A S, V27, P368
[4] JOHNSON CK, 1965, ORNL3794 REP

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