AN EFFICIENT, REGIOCONTROLLED SYNTHESIS OF 5-ARYL-2-CARBETHOXYPYRROLES FROM 3-ARYL-3-CHLOROPROPENIMINIUM SALTS

被引：38

作者：

GUPTON, JT ^{[1
]}

KROLIKOWSKI, DA ^{[1
]}

YU, RH ^{[1
]}

VU, P ^{[1
]}

SIKORSKI, JA ^{[1
]}

DAHL, ML ^{[1
]}

JONES, CR ^{[1
]}

机构：

[1] MONSANTO AGR CO,DIV NEW PROD,MONSANTO CO UNIT,ST LOUIS,MO 63198

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1992年 / 57卷 / 20期

关键词：

D O I：

10.1021/jo00046a033

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A variety of 3-aryl-3-chloropropeniminium salts react with alpha-amino acid esters under basic conditions to produce 2-carbethoxy-5-arylpyrroles in a regioselective manner. The overall process represents a short, efficient, and convergent synthesis of 2,5-disubstituted pyrroles, and azomethine ylides or azapentadienyl anions may be involved as intermediates.

引用

页码：5480 / 5483

页数：4

共 12 条

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