THE TRANSCRIPTIONAL CONTROL PROTEINS C-MYB AND V-MYB CONTAIN A BASIC REGION DNA-BINDING MOTIF

被引：13

作者：

CARR, MD ^{[1
]}

MOTT, RF ^{[1
]}

机构：

[1] NATL INST MED RES,MATH BIOL LAB,LONDON NW7 1AA,ENGLAND

来源：

FEBS LETTERS | 1991年 / 282卷 / 02期

关键词：

MYB; BASIC REGION DNA BINDING MOTIF;

D O I：

10.1016/0014-5793(91)80498-R

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A class of transcriptional control proteins, typified by c-Myb, are characterised by a highly conserved N-terminal DNA binding domain, which is composed of either 2 or 3 imperfect repeats of about 52 amino acids. A sequence homology search of the SWISSPROT protein sequence data bank with this region from mouse c-Myb has allowed us to identify an area near the C-terminus of repeat 2 that contains a short sequence motif, known as the basic region, which forms the DNA binding site in both leucine zipper and helix-loop-helix transcription factors. We therefore propose that this region of repeat 2 and the homologous part of repeat 3 will form the Myb DNA binding site.

引用

页码：293 / 294

页数：2