COEXPRESSION OF TRK FAMILY MEMBERS AND LOW-AFFINITY NEUROTROPHIN RECEPTORS IN RAT DORSAL-ROOT GANGLION NEURONS

被引：66

作者：

KASHIBA, H ^{[1
]}

NOGUCHI, K ^{[1
]}

UEDA, Y ^{[1
]}

SENBA, E ^{[1
]}

机构：

[1] WAKAYAMA MED COLL,DEPT ANAT 2,WAKAYAMA 640,JAPAN

来源：

MOLECULAR BRAIN RESEARCH | 1995年 / 30卷 / 01期

关键词：

TRK RECEPTOR; LOW-AFFINITY NEUROTROPHIN RECEPTOR; COEXPRESSION; DORSAL ROOT GANGLION NEURON; IN SITU HYBRIDIZATION; RAT;

D O I：

10.1016/0169-328X(94)00249-E

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We examined the colocalization of trk family and low-affinity neurotrophin receptor (LANR) mRNAs by means of in situ hybridization histochemistry in rat dorsal root ganglion (DRG) neurons. About 35-40%, 5%, and 15-20% of DRG neurons were positive for trkA, trkB, and trkC mRNAs, respectively. Each member of the trk family was coexpressed with LANR. The trkB mRNA-expressing neurons essentially lacked trkA and trkC mRNAs, and most of trkA and trkC mRNAs-expressing neurons (85-90%) belonged to different subpopulations, suggesting that they are involved in different functions.

引用

页码：158 / 164

页数：7

共 24 条

[11] TYROSINE PHOSPHORYLATION AND TYROSINE KINASE-ACTIVITY OF THE TRK PROTOONCOGENE PRODUCT INDUCED BY NGF [J].