XANTHONOLOL - A CALCIUM-CHANNEL AND BETA-ADRENOCEPTOR BLOCKER WITH VASODILATING PROPERTIES

被引：31

作者：

CHEN, IJ

LIOU, SJ

LIOU, SS

LIN, CN

机构：

[1] TAJEN PHARMACEUT JR COLL, PINGTUNG, TAIWAN

[2] KAOHSIUNG MED COLL, NAT PROD RES CTR, KAOHSIUNG 80708, TAIWAN

[3] KAOHSIUNG MED COLL, GRAD INST MED, KAOHSIUNG 80708, TAIWAN

来源：

GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM | 1993年 / 24卷 / 06期

关键词：

D O I：

10.1016/0306-3623(93)90430-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. Xanthonolol (0. 1-5.0 mg/kg, i.v.) reduced the blood pressure, heart rate, 2. In the isolated guinea-pig right atrium, xanthonolol (10(-6)-3 x 10(-4) M) produced long-lasting negative, inhibited L-isoproterenol-induced positive chronotropic effects, prevented the rate-increasing effects of increased extracellular Ca2+ (3.0-9.0 mM), and inhibited Ca2+ (3.0-9.0 mM)-induced heart rate-increase. 3. In the isolated guinea-pig thoracic aorta, the contractions induced by CaCl2 (0.1-5.0 mM) were inhibited by xanthonolol (10(-6)-10(-4) M). 4. Xanthonolol is suggested to have a calcium channel and beta adrenergic blocking effect with vasodilating properties.

引用

页码：1425 / 1433

页数：9

共 20 条

[1] CANSCORA-DECUSSATA (GENTIANACEAE) XANTHONES .3. PHARMACOLOGICAL STUDIES [J].