MEASUREMENTS OF PERTINENT CONCENTRATIONS OF OXYGEN INVIVO

被引：81

作者：

SWARTZ, HM

BOYER, S

GAST, P

GLOCKNER, JF

HU, H

LIU, KJ

MOUSSAVI, M

NORBY, SW

VAHIDI, N

WALCZAK, T

WU, M

CLARKSON, RB

机构：

[1] UNIV ILLINOIS,DEPT PHYSIOL & BIOPHYS,506 S MATHEWS,190 MED SCI BLDG,URBANA,IL 61801

[2] UNIV ILLINOIS,COLL VET MED,URBANA,IL 61801

[3] UNIV ILLINOIS,DEPT MED,URBANA,IL 61801

[4] CEN,CEA,DTA,LETI,DSYS,F-38041 GRENOBLE,FRANCE

来源：

MAGNETIC RESONANCE IN MEDICINE | 1991年 / 20卷 / 02期

关键词：

D O I：

10.1002/mrm.1910200217

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

A new method able to measure the concentration of oxygen in complex biological systems, including in vivo, has been developed using low‐frequency EPR and newly characterized free radicals that are very sensitive to the concentration of oxygen. The free radicals (fusinite and lithium phthalocyanine) are very stable in tissues (for at least 150 days), apparently nontoxic, and can reflect oxygen concentrations that are less than the Km of cytochrome oxidase (0.1 μM or lower). Their biological stability is indicated by the fact that repeated measurements with fusinite of the concentration of oxygen in skeletal muscle have been made in the same animal for more than 150 days without any change in sensitivity or signs of toxicity. © 1991 Academic Press, Inc. Copyright © 1991 Wiley‐Liss, Inc., A Wiley Company

引用

页码：333 / 339

页数：7

共 13 条

[1] INVIVO LOCALIZED ESR SPECTROSCOPY REFLECTING METABOLISM [J].