INHIBITORY EFFECTS OF 3'-METHYL-3-HYDROXY-CHALCONE ON PROLIFERATION OF HUMAN-MALIGNANT TUMOR-CELLS AND ON SKIN CARCINOGENESIS

被引：49

作者：

SATOMI, Y

机构：

[1] Department of Biochemistry, Kyoto Prefectural University of Medicine, Kyoto, 602, Kawaramachi, Hirokoji, Kamigyo‐ku

来源：

INTERNATIONAL JOURNAL OF CANCER | 1993年 / 55卷 / 03期

关键词：

D O I：

10.1002/ijc.2910550330

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

3'-methyl-3-hydroxy-chalcone (3'Me-3-C), a derivative of chalcone, inhibited the proliferation of various kinds of human malignant tumor cells, such as HGC-27 (gastric cancer), HeLa (cervical carcinoma), PANC-1 (pancreatic cancer) and GOTO (neuroblastoma). Flow-cytometric analysis of HGC-27 cells revealed that 3'Me-3-C perturbed the cell cycle, i.e., it delayed passage through the S phase, and/or caused arrest in the G0/G1 phase. 3'Me-3-C inhibited the binding of [6,7-H-3]estradiol to type-II estrogen-binding sites dose-dependently, and altered the pattern of protein synthesis and phosphorylation, which may explain 3'Me-3-C-induced inhibition of cell proliferation. In addition, 3'Me-3-C also suppressed the promoting activity of 12-O-tetradecanoylphorbol-13-acetate on skin carcinogenesis in 7,12-dimethylbenz[a]anthracene-initiated mice. (C) 1993 Wiley-Liss, Inc.

引用

页码：506 / 514

页数：9

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