GLUCOCORTICOID INDEPENDENCE OF ACUTE THYMIC INVOLUTION INDUCED BY LYMPHOTOXIN AND ESTROGEN

被引：43

作者：

HIRAHARA, H ^{[1
]}

OGAWA, M ^{[1
]}

KIMURA, M ^{[1
]}

IIAI, T ^{[1
]}

TSUCHIDA, M ^{[1
]}

HANAWA, H ^{[1
]}

WATANABE, H ^{[1
]}

ABO, T ^{[1
]}

机构：

[1] NIIGATA UNIV,SCH MED,DEPT IMMUNOL,NIIGATA,NIIGATA 951,JAPAN

来源：

CELLULAR IMMUNOLOGY | 1994年 / 153卷 / 02期

关键词：

D O I：

10.1006/cimm.1994.1038

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Acute thymic involution is known to be induced under conditions of physical stress, bacterial infections, and malignancies. It is speculated that glucocorticoids, tumor necrosis factor (TNF), and other factors may act as mediators for the thymic involution under such conditions. It was herein investigated whether either lymphotoxin (TNFβ) or estrogen could induce thymic involution without the help of glucocorticoids. Interestingly, both lymphotoxin or estrogen alone induced profound thymic involution even in adrenalectomized mice. In contrast to glucocorticoids, which induce lymphocytopenia throughout the organs, lymphotoxin and estrogen did not induce lymphocytopenia in the peripheral organs. More importantly, lymphotoxin and estrogen rather stimulated extrathymic T cells in the liver and other organs. These results suggest that lymphotoxin and estrogen per se might be important regulators of immune systems. © 1994 Academic Press. All rights reserved.

引用

页码：401 / 411

页数：11