MOLECULAR-CLONING AND CHROMOSOMAL LOCALIZATION OF THE HUMAN ALPHA(7)-NICOTINIC RECEPTOR SUBUNIT GENE (CHRNA7)

被引：87

作者：

CHINI, B

RAIMOND, E

ELGOYHEN, AB

MORALLI, D

BALZARETTI, M

HEINEMANN, S

机构：

[1] SALK INST BIOL STUDIES,MOLEC NEUROBIOL LAB,LA JOLLA,CA 92037

[2] DIPARTIMENTO GENET & MICROBIOL A BUZZATI TRAVERSO,I-27100 PAVIA,ITALY

来源：

GENOMICS | 1994年 / 19卷 / 02期

关键词：

D O I：

10.1006/geno.1994.1075

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We have isolated cDNA and genomic clones coding for the human alpha(7) neuronal nicotinic receptor subunit, the major component of brain nicotinic receptors that are blocked by alpha-bungarotoxin. The human alpha(7) neuronal nicotinic cDNA encodes a mature protein of 479 amino acids that is highly homologous to the rat alpha(7) neuronal nicotinic subunit (90%). We have mapped the human alpha(7)-nicotinic receptor subunit gene to chromosome 15, band q14, a region frequently rearranged in patients carrying a bisatellite 15 chromosome, large inv dup (15), whose clinical features include mental retardation and seizures. (C) 1994 Academic Press, Inc.

引用

页码：379 / 381

页数：3

共 15 条

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