STRUCTURE-BASED DRUG DESIGN

被引：62

作者：

COLMAN, PM

机构：

[1] Biomolecular Research Institute, Parkville, 3052

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1994年 / 4卷 / 06期

关键词：

D O I：

10.1016/0959-440X(94)90268-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

There are now many successful examples of the design of new ligands based on knowledge of target protein structures. In most cases those ligands are unsuitable as drugs because of problems of toxicity, stability or bioavailability. The past twelve months have also seen the description of the structures of many proteins which are either known to be targets for existing drugs or have clear potential to be utilized in therapy.

引用

页码：868 / 874

页数：7

共 66 条

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