EFFECTS OF LINALOOL ON GLUTAMATERGIC SYSTEM IN THE RAT CEREBRAL-CORTEX

被引：152

作者：

ELISABETSKY, E ^{[1
]}

MARSCHNER, J ^{[1
]}

SOUZA, DO ^{[1
]}

机构：

[1] UNIV FED RIO GRANDE SUL, INST BIOCIENCIAS, DEPT BIOQUIM, BR-90049 PORTO ALEGRE, RS, BRAZIL

来源：

NEUROCHEMICAL RESEARCH | 1995年 / 20卷 / 04期

关键词：

GLUTAMATE; ANTICONVULSANT; LINALOOL; BINDING;

D O I：

10.1007/BF00973103

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Linalool is a monoterpene compound reported to be a major component of essential oils in various aromatic species. Several Linalool-producing species are used in traditional medical systems, including Aeolanthus suaveolens G. Dom (Labiatae) used as anticonvulsant in the Brazilian Amazon. Psychopharmacological in vivo evaluation of Linalool showed that this compound have dose-dependent marked sedative effects at the Central Nervous System, including hypnotic, anticonvulsant and hypothermic properties. The present study reports an inhibitory effect of Linalool on Glutamate binding in rat cortex. It is suggested that this neurochemical effect might be underlining Linalool psychopharmacological effects. These findings provide a rational basis for many of the traditional medical use of Linalool producing plant species.

引用

页码：461 / 465

页数：5

共 26 条

[11]

ELISABETSKY E, 1986, AMAZON CABOCLO HISTO, V32, P243

[12]

Farnsworth NR, 1988, BIODIVERSITY, P83

[13] GLUTAMATE - A NEUROTRANSMITTER IN MAMMALIAN BRAIN [J].

FONNUM, F .

JOURNAL OF NEUROCHEMISTRY, 1984, 42 (01) :1-11

[14] DISEASE ETIOLOGIES IN NON-WESTERN MEDICAL SYSTEMS [J].

FOSTER, GM .

AMERICAN ANTHROPOLOGIST, 1976, 78 (04) :773-782

[15]

Gasic G P, 1991, Curr Opin Neurobiol, V1, P20, DOI 10.1016/0959-4388(91)90006-S

[16] G-PROTEINS [J].

HEPLER, JR ;

GILMAN, AG .

TRENDS IN BIOCHEMICAL SCIENCES, 1992, 17 (10) :383-387

[17]

LOWRY OH, 1951, J BIOL CHEM, V193, P265

[18]

MELDRUM B, 1990, PROG CLIN BIOL RES, V361, P31

[19]

SAMUELSSON G, 1989, ACTA PHARM NORDICA, V1, P111

[20]

Santos C.A.D.M., 1988, PLANTAS MED HERBARIU

← 1 2 3 →