THE INFLUENCE OF VARIOUS ANESTHETICS ON THE RELEASE AND METABOLISM OF THYROID-HORMONES - RESULTS OF 2 CLINICAL-STUDIES

被引：16

作者：

BORNER, U ^{[1
]}

KLIMEK, M ^{[1
]}

SCHOENGEN, H ^{[1
]}

LYNCH, J ^{[1
]}

PESCHAU, C ^{[1
]}

SCHICHA, H ^{[1
]}

机构：

[1] UNIV COLOGNE, FAC MED, DEPT NUCL MED, W-5000 COLOGNE, GERMANY

来源：

ANESTHESIA AND ANALGESIA | 1995年 / 81卷 / 03期

关键词：

D O I：

10.1097/00000539-199509000-00034

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Normal functioning of the thyroid gland during surgery is important, but few data are available on the possible interactions between anesthesia and thyroid hormones. In two independent studies we examined the influence of different types of general anesthesia on the plasma levels of the thyroid hormones. They revealed an intraoperative increase of free thyroxine (fT(4)) and total thyroxine (tT(4)) in plasma to approximately 150% of preanesthesia levels when enflurane was used. No increase in thyroid-stimulating hormone (TSH) secretion was noted prior to this. The increase was not due to a quantitative change in the binding proteins. The plasma levels of fT(4) and tT(4) returned to normal postoperatively; however, no accompanying increase in plasma triiodothyronine levels was observed. Hence we assume the increase to be due to hormone release from thyroid and/or extrathyroidal stores-an intercompartmental shifting.

引用

页码：612 / 618

页数：7

共 24 条

[11]

HAGENFELDT I, 1979, ACTA CHIR SCAND, V145, P77

[12] RELEASE OF THYROXINE FROM LIVER DURING ANESTHESIA AND SURGERY [J].

HARLAND, WA ;

HORTON, PW ;

STRANG, R ;

FITZGERALD, B ;

RICHARDS, JR ;

HOLLOWAY, KB .

BRITISH JOURNAL OF ANAESTHESIA, 1974, 46 (11) :818-820

[13] INCREASED THYROXINE SECRETION FOLLOWING SURGICAL OPERATION [J].

HARLAND, WA ;

ORR, JS ;

RICHARDS, JR .

SCOTTISH MEDICAL JOURNAL, 1972, 17 (03) :92-&

[14]

JOHNSTONE RE, 1976, CLIN CHEM, V22, P217

[15] THYROTROPIN, FREE AND TOTAL TRIIODOTHYRONINE, AND THYROXINE IN SERUM DURING SURGERY [J].

KEHLET, H ;

KLAUBER, PV ;

WEEKE, J .

CLINICAL ENDOCRINOLOGY, 1979, 10 (02) :131-136

[16]

Kirby R, 1972, Adv Exp Med Biol, V33, P165

[17] ALTERATIONS IN SERUM CONCENTRATIONS OF T4, T3 AND R-T3 IN NORMOGLYCEMIC GLUCOSE CLAMP-EVIDENCE OF INTERCOMPARTMENTAL SHIFTING [J].

LOOS, U ;

GRAU, R ;

BEISCHER, W ;

DUNTAS, L ;

KERNER, W ;

SCHMIDT, M ;

PFEIFFER, EF .

HORMONE AND METABOLIC RESEARCH, 1981, 13 (02) :118-119

[18]

MATSUKI A, 1981, Agressologie, V22, P225

[19]

MATSUKI A, 1983, ENDOCRINOLOGY ANAEST, P65

[20] EFFECT OF HALOTHANE, METHOXYFLURANE ANESTHESIA AND SURGERY ON PLASMA THYROID-STIMULATING HORMONE (TSH) LEVELS IN MAN [J].

OYAMA, T ;

MATSUKI, A ;

KUDO, T .

ANAESTHESIA, 1972, 27 (01) :2-&

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