EFFECTS OF SNAKE-VENOM PROTEINS ON BLOOD-PLATELETS

被引：101

作者：

KINI, RM

EVANS, HJ

机构：

[1] Department of Biochemistry and Molecular Biophysics, Medical College of Virginia, Virginia Commonwealth University, Richmond

来源：

TOXICON | 1990年 / 28卷 / 12期

关键词：

D O I：

10.1016/0041-0101(90)90155-Z

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

R. M. Kini and H. J. Evans. Review article-Effects of snake venom proteins on blood platelets. Toxicon 28, 1387-1422, 1990.-Snake venoms are complex mixtures which contain pharmacologically active polypeptides and proteins. Several snake venom constituents interfere in platelet aggregation, an important cellular process in thrombosis and hemostasis. These components range in size from small molecular weight polypeptides to high molecular weight proteins. Some of the proteins are enzymes, such as phospholipase A2, proteinases, nucleotidases, or l-amino acid oxidase, while others do not exhibit enzymatic activity. These components may initiate and/or inhibit platelet aggregation. Some venom factors induce platelet agglutination. This review deals with the physical characteristics of these venom factors, the mechanisms of their platelet effects, structure-function relationships, and their physiological significance. © 1990.

引用

页码：1387 / 1422

页数：36

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