CLONAL CHROMOSOME CHANGES IN RENAL-CARCINOMA DO NOT CORRELATE WITH CLINICAL STAGES AND HISTOPATHOLOGIC GRADES

被引：13

作者：

GRANATA, P

PORTENTOSO, P

MINELLI, E

RIGHI, R

MERONI, E

BONO, AV

POZZI, E

SALVADORE, M

SIMI, P

CASALONE, R

机构：

[1] UNIV PAVIA,CP 217,I-27100 PAVIA,ITALY

[2] UNIV PISA,OSPED CIRCOLO VARESE,PEDIAT CLIN,ANALIIST LAB,SEZ CITOGENET,I-56100 PISA,ITALY

[3] UNIV PISA,OSPED CIRCOLO VARESE,DIV UROL,I-56100 PISA,ITALY

[4] UNIV PISA,OSPED CIRCOLO VARESE,SERV ANAT PATOL,I-56100 PISA,ITALY

来源：

CANCER GENETICS AND CYTOGENETICS | 1992年 / 64卷 / 01期

关键词：

D O I：

10.1016/0165-4608(92)90318-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We analyzed the correlations between chromosome abnormalities and clinical and histopathologic characteristics in 77 cases of renal cell carcinoma [RCC]. Chromosome changes such as +5,+7,+8,+10,+18,+X,+Y, and -Y have been excluded from the analysis because they also occur in nonneoplastic kidney tissue and cytogenetic analysis indicates that these anomalies are not involved in tumor progression. The most frequent specific chromosome abnormalities in this sample were 3p rearrangements, trisomy 17, and hyperdiploidy and were not related to tumor stage or grade or to development of distant metastases.

引用

页码：30 / 34

页数：5

共 19 条

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