THE MOLECULAR-BASIS OF KINDLING

被引：59

作者：

MODY, I ^{[1
]}

机构：

[1] UNIV TEXAS,SW MED CTR,DEPT NEUROL,DALLAS,TX 75235

来源：

BRAIN PATHOLOGY | 1993年 / 3卷 / 04期

关键词：

D O I：

10.1111/j.1750-3639.1993.tb00767.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Kindling is an experimental model of epilepsy that involves activity-dependent changes in neuronal structure and function. During kindling, pathological changes may occur at several organizational levels of the nervous system, from alterations in gene-expression in individual neurons to the loss of specific neuronal populations and rearrangement of synaptic connectivity resulting from sustained stimulation of major excitatory pathways. This review summarizes recent developments in alterations at single neuronal and molecular levels that may be responsible for kindling epileptogenesis.

引用

页码：395 / 403

页数：9

共 123 条

[51] THE INOSITOL 1,4,5-TRISPHOSPHATE PATHWAY MEDIATES CHOLINERGIC POTENTIATION OF RAT HIPPOCAMPAL NEURONAL RESPONSES TO NMDA [J].