SYNTHESIS OF (2-ARYLINDOL-3-YL)ACETAMIDES AS PROBES OF MITOCHONDRIAL STEROIDOGENESIS - A NEW MECHANISM FOR GABA(A) RECEPTOR MODULATION

被引：8

作者：

KOZIKOWSKI, AP ^{[1
]}

MA, D ^{[1
]}

ROMEO, E ^{[1
]}

AUTA, J ^{[1
]}

PAPADOPOULOS, V ^{[1
]}

PUIA, G ^{[1
]}

COSTA, E ^{[1
]}

GUIDOTTI, A ^{[1
]}

机构：

[1] FIDIA GEORGETOWN INST NEUROSCI, WASHINGTON, DC USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1992年 / 31卷 / 08期

关键词：

D O I：

10.1002/anie.199210601

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

High affinity and selectivity for mitochondrial DBI receptors characterize indolylacetamides 1. These compounds stimulate the production of neurosteroids in glial cells allowing possible indirect modulation of the γ‐aminobutyric acid receptor complex. In behavioral experiments with rats, 1a was found to have antineophobic action, that is, it reduces the fear of novelty. (Figure Presented.) Copyright © 1992 by VCH Verlagsgesellschaft mbH, Germany

引用

页码：1060 / 1062

页数：3

共 20 条

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