INVOLVEMENT OF D-AMINO-ACID OXIDASE IN ELIMINATION OF D-SERINE IN MOUSE-BRAIN

被引：72

作者：

NAGATA, Y

机构：

[1] Department of Life Science, Himeji Institute of Technology, Himeji, 671-22

来源：

EXPERIENTIA | 1992年 / 48卷 / 08期

关键词：

D-AMINO ACID OXIDASE; D-SERINE; CEREBELLUM; CEREBRUM;

D O I：

10.1007/BF02124295

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The physiological role of D-amino acid oxidase (EC 1.4.3.3) in mouse brain is described. The presence of D-enantiomers of neutral common amino acids was surveyed in the brain. D-serine was shown to be present at high concentration only in regions where the enzyme activity was low. In normal mice whose D-amino acid oxidase activity was much higher in the cerebellum than in the cerebrum, free D-serine content was apparently lower in the cerebellum than in the cerebrum. In mice of a mutant strain lacking D-amino acid-oxidase activity, the free D-serine level was remarkably high both in the cerebrum and cerebellum. The results suggest that the enzyme is involved in the elimination of free D-serine in the cerebellum.

引用

页码：753 / 755

页数：3

共 13 条

[1] REACTIONS OF CYSTEAMINE AND OTHER AMINE METABOLITES WITH GLYOXYLATE AND OXYGEN CATALYZED BY MAMMALIAN D-AMINO-ACID OXIDASE [J].