REGULATION OF TCR-ALPHA AND TCR-BETA GENE ALLELIC EXCLUSION DURING T-CELL DEVELOPMENT

被引：258

作者：

MALISSEN, M

TRUCY, J

JOUVINMARCHE, E

CAZENAVE, PA

SCOLLAY, R

MALISSEN, B

机构：

[1] INST PASTEUR,DEPT IMMUNOL,F-75724 PARIS 15,FRANCE

[2] ROYAL MELBOURNE HOSP,WALTER & ELIZA HALL INST MED RES,PARKVILLE,VIC 3050,AUSTRALIA

来源：

IMMUNOLOGY TODAY | 1992年 / 13卷 / 08期

关键词：

D O I：

10.1016/0167-5699(92)90044-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Early in their development, most T cells become committed to the expression of one, and only one, TCR alpha-beta-combination. How do T cells achieve this TCR allelic exclusion? This article discusses the configuration and expression of TCR alpha and beta-genes in mature T-cell lines and TCR alpha-beta-transgenic mice, and proposes three nonexclusive models to account for the significant occurrence of T cells with two productive alpha-gene rearrangements.

引用

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页码：315 / 322

页数：8

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