SYNTHESIS AND BIOLOGICAL-ACTIVITY OF THE HEXALIN MOIETY OF COMPACTIN (ML-236B)

被引：25

作者：

HEATHCOCK, CH ^{[1
]}

TASCHNER, MJ ^{[1
]}

ROSEN, T ^{[1
]}

THOMAS, JA ^{[1
]}

HADLEY, CR ^{[1
]}

POPJAK, G ^{[1
]}

机构：

[1] UNIV CALIF LOS ANGELES,SCH MED,DEPT BIOL CHEM,LOS ANGELES,CA 90024

来源：

TETRAHEDRON LETTERS | 1982年 / 23卷 / 46期

关键词：

D O I：

10.1016/S0040-4039(00)85703-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

引用

页码：4747 / 4750

页数：4

共 18 条

[1] MEVINOLIN - A HIGHLY POTENT COMPETITIVE INHIBITOR OF HYDROXYMETHYLGLUTARYL-COENZYME-A REDUCTASE AND A CHOLESTEROL-LOWERING AGENT [J].

ALBERTS, AW ;

CHEN, J ;

KURON, G ;

HUNT, V ;

HUFF, J ;

HOFFMAN, C ;

ROTHROCK, J ;

LOPEZ, M ;

JOSHUA, H ;

HARRIS, E ;

PATCHETT, A ;

MONAGHAN, R ;

CURRIE, S ;

STAPLEY, E ;

ALBERSSCHONBERG, G ;

HENSENS, O ;

HIRSHFIELD, J ;

HOOGSTEEN, K ;

LIESCH, J ;

SPRINGER, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (07) :3957-3961

[2] CRYSTAL AND MOLECULAR-STRUCTURE OF COMPACTIN, A NEW ANTIFUNGAL METABOLITE FROM PENICILLIUM-BREVICOMPACTUM [J].

BROWN, AG ;

SMALE, TC ;

KING, TJ ;

HASENKAMP, R ;

THOMPSON, RH .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1976, (11) :1165-1173

[3] LITHIUM TRI-SEC-BUTYLBOROHYDRIDE - NEW REAGENT FOR REDUCTION OF CYCLIC AND BICYCLIC KETONES WITH SUPER STEREOSELECTIVITY - REMARKABLY SIMPLE AND PRACTICAL PROCEDURE FOR CONVERSION OF KETONES TO ALCOHOLS IN EXCEPTIONALLY HIGH STEREOCHEMICAL PURITY [J].

BROWN, HC ;

KRISHNAMURTHY, S .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1972, 94 (20) :7159-+

[4] VINYL-LITHIUM REAGENTS FROM ARENESULFONYLHYDRAZONES [J].

CHAMBERLIN, AR ;

STEMKE, JE ;

BOND, FT .

JOURNAL OF ORGANIC CHEMISTRY, 1978, 43 (01) :147-154

[5]

COREY EJ, 1971, J ORG CHEM, V36, P4144

[6] DIELS-ALDER REACTIONS OF TRANS-1-METHOXY-3-TRIMETHYLSILYLOXY-1,3-BUTADIENE [J].

DANISHEFSKY, S ;

KITAHARA, T ;

YAN, CF ;

MORRIS, J .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1979, 101 (23) :6996-7000

[7] SYNTHESIS OF THE HEXAHYDRONAPHTHALENE MOIETY OF (+/-)-COMPACTIN (ML-236B) [J].

DEUTSCH, EA ;

SNIDER, BB .

JOURNAL OF ORGANIC CHEMISTRY, 1982, 47 (13) :2682-2684

[8]

EDWARDS PA, 1979, J LIPID RES, V20, P40

[9] COMPETITIVE INHIBITION OF 3-HYDROXY-3-METHYLGLUTARYL COENZYME A REDUCTASE BY ML-236A AND ML-236B FUNGAL METABOLITES, HAVING HYPOCHOLESTEROLEMIC ACTIVITY [J].

ENDO, A ;

KURODA, M ;

TANZAWA, K .

FEBS LETTERS, 1976, 72 (02) :323-326

[10] ML-236A, ML-236B, AND ML-236C, NEW INHIBITORS OF CHOLESTEROGENESIS PRODUCED BY PENICILLIUM CITRINUM [J].

ENDO, A ;

KURODA, M ;

TSUJITA, Y .

JOURNAL OF ANTIBIOTICS, 1976, 29 (12) :1346-1348

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