ENDOGENOUS D-SERINE IN RAT-BRAIN - N-METHYL-D-ASPARTATE RECEPTOR-RELATED DISTRIBUTION AND AGING

被引：315

作者：

HASHIMOTO, A

NISHIKAWA, T

OKA, T

TAKAHASHI, K

机构：

[1] NATL CTR NEUROL & PSYCHIAT,NATL INST NEUROSCI,DIV MENTAL DISORDER RES,4-1-1 OGAWA HIGASHI,KODAIRA,TOKYO 187,JAPAN

[2] NIPPON OIL & FATS CO LTD,TSUKUBA RES LAB,IBARAKI,JAPAN

来源：

JOURNAL OF NEUROCHEMISTRY | 1993年 / 60卷 / 02期

关键词：

D-SERINE; GLYCINE; STRYCHNINE-INSENSITIVE GLYCINE SITE; N-METHYL-D-ASPARTATE RECEPTOR; DEVELOPMENT; DISTRIBUTION;

D O I：

10.1111/j.1471-4159.1993.tb03219.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recently, a substantial amount of free D-serine has been demonstrated in rat brain, although it has long been presumed that D-amino acids are uncommon in mammals. The anatomical distribution and age-related changes in endogenous D-serine have been examined here to obtain insight into its physiological functions. Free D-serine exclusively occurs in brains, with a persistent high content from birth to at least 86 postnatal weeks. The patterns of the regional variations and the postnatal changes in brain D-serine are closely correlated with those of the N-methyl-D-aspartate (NMDA)-type excitatory amino acid receptor. BecaUSe D-serine potentiates NMDA receptor-mediated transmission by selective stimulation of the strychnine-insensitive glycine site of the NMDA receptor, it is proposed that D-serine is a novel candidate as an intrinsic ligand for the glycine site in mammalian brain.

引用

页码：783 / 786

页数：4

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