POLYMERIC PORPHYRINS AS NEW PHOTOCATALYSTS IN PHOTODYNAMIC THERAPY OF CANCER

被引：17

作者：

WOHRLE, D

ARDESHIRPUR, A

HEUERMANN, A

MULLER, S

GRASCHEW, G

RINNEBERG, H

KOHL, M

NEUKAMMER, J

机构：

[1] DEUTSCH KREBSFORSCHUNGSZENTRUM, INST RADIOL & PATHOPHYSIOL, W-6900 HEIDELBERG, GERMANY

[2] PHYS TECH BUNDESANSTALT, W-1000 BERLIN 10, GERMANY

来源：

MAKROMOLEKULARE CHEMIE-MACROMOLECULAR SYMPOSIA | 1992年 / 59卷

关键词：

D O I：

10.1002/masy.19920590104

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Photodynamic therapy and diagnosis (PDT) is described as an efficient clinical method for the treatment of cancer patients using hematoporphyrin derivative (Hpd) as sensitizer. Newly developed metal-containing porphyrin type compounds are potential agents for PDT. A concept for covalently bound polymeric metal-containing or metal-free sensitizers is discussed. First results of these polymeric sensitizers are reported from in vivo experiments. High tumor accumulation up to 30 % was observed. Results of fluorescence diagnosis are shown.

引用

页码：17 / 33

页数：17

共 37 条

[1]

[Anonymous], J INORG ORGANOMET PO

[2]

ARDESHIRPUR A, 1990, 3RD BIENN M INT PHOT

[3] MESO-TETRA(HYDROXYPHENYL)PORPHYRINS, A NEW CLASS OF POTENT TUMOR PHOTOSENSITIZERS WITH FAVORABLE SELECTIVITY [J].