BIODEGRADABLE DELIVERY SYSTEM FOR SINGLE-STEP IMMUNIZATION WITH TETANUS TOXOID

被引：43

作者：

RAGHUVANSHI, RS ^{[1
]}

SINGH, M ^{[1
]}

TALWAR, GP ^{[1
]}

机构：

[1] NATL INST IMMUNOL,ARUNA ASAF ALI MARG,NEW DELHI 110067,INDIA

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1993年 / 93卷 / 1-3期

关键词：

BIODEGRADABLE POLYMER; POLY(DL-LACTIDE-CO-GLYCOLIDE); TETANUS TOXOID; VACCINE; CONTROLLED DELIVERY; NEONATAL TETANUS;

D O I：

10.1016/0378-5173(93)90188-L

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Tetanus toxoid (TT) loaded biodegradable microspheres were prepared from poly(DL-lactide-co-glycolide) (monomer ratio 65:35) of Mol. Wt 75000. The method of preparation was emulsification-solvent evaporation. In vitro vaccine release data are discussed. An in vivo immune response study was performed on rats. Results of immunization with the conventional schedule of TT and encapsulated TT until 5 months after immunization are presented, which were found to be comparable.

引用

页码：R1 / R5

页数：5

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