ISOLATION OF DECOMPOSITION PRODUCTS OF TYLOSIN USING LIQUID-CHROMATOGRAPHY

被引：30

作者：

PAESEN, J ^{[1
]}

CYPERS, W ^{[1
]}

BUSSON, R ^{[1
]}

ROETS, E ^{[1
]}

HOOGMARTENS, J ^{[1
]}

机构：

[1] KATHOLIEKE UNIV LEUVEN,FAC FARMACEUT WETENSCHAPPEN,FARMACEUT CHEM & ANAL GENEESMIDDELEN LAB,B-3000 LOUVAIN,BELGIUM

来源：

JOURNAL OF CHROMATOGRAPHY A | 1995年 / 699卷 / 1-2期

关键词：

D O I：

10.1016/0021-9673(94)01269-K

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Decomposition products of tylosin A were isolated using open column chromatography and preparative liquid chromatography. Two decomposition products, formed in slightly alkaline medium, were identified as epimers of tylosin A aldol, one of which has been described previously. Another decomposition product was formed on exposure of a tylosin A solution to light. Isomerization of the double bond between C-12-C-13 takes place, resulting in the formation of the hitherto unreported isotylosin A.

引用

页码：99 / 106

页数：8

共 13 条

[1] PHARMACOPOEIAL PROCEDURE FOR THE DETERMINATION OF TYLOSIN FACTORS BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY [J].