DIFFERENCES IN SENSITIVITY TO NEUROLEPTIC BLOCKADE - MEDIAL FOREBRAIN-BUNDLE VERSUS FRONTAL-CORTEX SELF-STIMULATION

被引：23

作者：

CORBETT, D ^{[1
]}

机构：

[1] MEM UNIV NEWFOUNDLAND, DEPT PSYCHOL, St John A1B 3V6, NEWFOUNDLAND, CANADA

来源：

BEHAVIOURAL BRAIN RESEARCH | 1990年 / 36卷 / 1-2期

基金：

加拿大自然科学与工程研究理事会;

关键词：

Dopamine; Medial forebrain bundle; Prefrontal cortex; Self-stimulation;

D O I：

10.1016/0166-4328(90)90163-9

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The effects of systemic injections of the dopamine receptor antagonist, cis-flupenthixol were tested on intracranial self-stimulation at electrode sites in the medial forebrain bundle and the medial prefrontal cortex. Changes in the reward effectiveness of the brain stimulation were assessed using a curve-shift paradigm. Low to moderate doses of cis-flupenthixol (0.05, 0.1 and 0.15 mg/kg) consistently produced larger upward shifts in the rate-frequency function for medial forebrain bundle than for medial prefrontal self-stimulation. At the highest doses of cis-flupenthixol (0.15 and 0.2 mg/kg), some of the medial forebrain bundle rats failed to respond, whereas all medial prefrontal rats responded at these doses. These results demonstrate that medial forebrain bundle self-stimulation is much more dependent on dopamine systems than is prefrontal cortex self-stimulation. © 1990.

引用

页码：91 / 96

页数：6