THE 90-KDA HEAT-SHOCK PROTEIN PROTECTS MAMMALIAN-CELLS FROM THERMAL-STRESS BUT NOT FROM VIRAL-INFECTION

被引：55

作者：

BANSAL, GS ^{[1
]}

NORTON, PM ^{[1
]}

LATCHMAN, DS ^{[1
]}

机构：

[1] UNIV COLL & MIDDLESEX SCH MED,DEPT BIOCHEM,MED MOLEC BIOL UNIT,WINDEYER BLDG,CLEVELAND ST,LONDON W1P 6DB,ENGLAND

来源：

EXPERIMENTAL CELL RESEARCH | 1991年 / 195卷 / 02期

关键词：

D O I：

10.1016/0014-4827(91)90377-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Using an anti-sense RNA approach, a mouse cell line containing dramatically reduced levels of the 90-kDa heat shock protein (hsp90) has been isolated. This line shows reduced growth at mildly elevated temperatures and reduced survival at highly elevated temperatures but is no more sensitive to herpes simplex virus infection than the parental cells. This is the first direct evidence of a role for an individual mammalian hsp in thermotolerance and suggests that individual hsps may be of different value in the response to various types of Stress. © 1991.

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页码：303 / 306

页数：4

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