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Meiotic recombination hotspots

被引：299
作者：
Lichten, M
Goldman, ASH
机构：
[1] Laboratory of Biochemistry, Division of Cancer Biology, National Cancer Institute, Bethesda
来源：
ANNUAL REVIEW OF GENETICS | 1995年 / 29卷
关键词：
crossing-over; gene conversion; meiosis; chromosome structure; chiasmata;
D O I：
10.1146/annurev.ge.29.120195.002231
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Meiotic recombination occurs more frequently in some regions of the eukaryotic genome than in others, with variations of several orders of magnitude observed in frequencies of meiotic exchange per unit physical distance. This article reviews what is known about meiotic recombination hotspots loci, or regions that display a greater than average frequency of meiotic exchange. Hotspots have been most intensively studied in Saccharomyces cerevisiae, which is a major focus of this article. Also reviewed is the current state of knowledge regarding hotspots in other fungi, in maize, in nematodes, in mice, and in humans.
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页码：423 / 444
页数：22
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