SELECTIVE INTESTINAL DECONTAMINATION FOR PREVENTION OF WOUND COLONIZATION IN SEVERELY BURNED PATIENTS - A RETROSPECTIVE ANALYSIS

被引：20

作者：

MANSON, WL

KLASEN, HJ

SAUER, EW

OLIEMAN, A

机构：

[1] Laboratory for Public Health, Groningen

[2] Burn Unit, Roman Catholic Hospital, Groningen

来源：

BURNS | 1992年 / 18卷 / 02期

关键词：

D O I：

10.1016/0305-4179(92)90002-C

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

In this study the effect of selective intestinal decontamination of the digestive tract (SDD) on wound colonization was investigated. Ninety-one patients with at least 25 per cent total burned surface area (TBSA) were included in this study. All patients received oral polymyxin. In 63 patients oral co-trimoxazole and amphotericin B were added to the regimen. The addition of co-trimoxazole decreased the incidence of Enterobacteriaceae wound colonization from 71 per cent to 11 per cent (P < 0.005). Colonization with Proteus was eliminated in patients treated with co-trimoxazole, compared with an incidence of 36 per cent in the group treated with polymyxin alone (P < 0.001). The addition of amphotericin B decreased yeast colonization of the burn wound from 39 per cent to 10 per cent (P < 0.005). A close relation was observed between burn wound colonization and colonization of the gastrointestinal tract. No resistant bacterial strains emerged during the period of study. These results suggest that SDD is an effective method for prevention of wound colonization. Further controlled studies are needed to establish the role of SDD in preventing burn wound colonization and wound sepsis.

引用

页码：98 / 102

页数：5

共 35 条

[11]

Kidson, Lowbury, Candida infections of burns, Burns, 6, (1979)

[12]

Lawrence, The bacteriology of burns, J. Hosp. Infect., 6, (1985)

[13]

Ledingham, Alcock, Eastaway, Et al., Triple regimen of selective decontamination of the digestive tract, systemic cefotaxime, and microbiological surveillance for prevention of acquired infection in intensive care, Lancet, 1, (1988)

[14]

Luterman, Dasco, Curreri, Infections in burn patients, Am. J. Med., 81, (1986)

[15]

Manson, Westerveld, Klasen, Selective intestinal decontamination of the digestive tract for infection prophylaxis in severely burned patients, Scand. J. Plast. Reconstr. Surg., 21, (1987)

[16]

Manson, Dijkema, Klasen, Prevention of wound colonization of mice receiving thermal injury, Burns, 16, (1990)

[17]

McManus, Mason, McManus, Et al., Twenty-five year review of Pseudomonas aeruginosa bacteremia in a burn centre, Eur. J. Clin. Microbiol., 4, (1985)

[18]

Monafo, An overview of infection control, J. Trauma, 19, (1979)

[19]

Monafo, Brentano, Gravens, Et al., Gas gangrene and mixed clostridial infections of muscles, complicating deep thermal burns, Arch. Surg., 92, (1966)

[20]

Moncrief, Topical antibacterial therapy of the burn wound, Clin. Plast. Surg., 1, (1974)

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