BIOLOGICAL RECEPTORS MEDIATE ANTIPROLIFERATIVE ACTION OF ATRIAL-NATRIURETIC-PEPTIDE IN CULTURED MESANGIAL CELLS

被引：29

作者：

HANEDA, M ^{[1
]}

KIKKAWA, R ^{[1
]}

KOYA, D ^{[1
]}

SAKAMOTO, K ^{[1
]}

NAKANISHI, S ^{[1
]}

MATSUDA, Y ^{[1
]}

SHIGETA, Y ^{[1
]}

机构：

[1] KYOWA HAKKO KOGYO CO LTD,TOKYO RES LABS,TOKYO 194,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1993年 / 192卷 / 02期

关键词：

D O I：

10.1006/bbrc.1993.1463

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The mechanism of anti-proliferative action of atrial natriuretic peptide (ANP) was examined in cultured mesangial cells. HS-142-1, a selective antagonist for ANP biological receptors, inhibited ANP-induced cellular cGMP accumulation and prevented ANP-induced inhibition of both serum-stimulated incorporation of 3H-thymidine and cell proliferation. Des-[Gln18, Ser19, Gly20, Leu21, Gly22]-ANP4-23-NH2 (C-ANP) failed to inhibit 3H- thymidine incorporation. These results indicate that anti-proliferative action of ANP is mediated by the biological receptors in cultured mesangial cells. © 1993 Academic Press, Inc.

引用

页码：642 / 648

页数：7

共 20 条

[1] ATRIAL NATRIURETIC FACTOR INHIBITS PROLIFERATION OF VASCULAR SMOOTH-MUSCLE CELLS STIMULATED BY PLATELET-DERIVED GROWTH-FACTOR
ABELL, TJ
RICHARDS, AM
IKRAM, H
ESPINER, EA
YANDLE, T
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 160 (03) : 1392 - 1396
[2] GROWTH-REGULATORY PROPERTIES OF ATRIAL-NATRIURETIC-FACTOR
APPEL, RG
[J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1992, 262 (06): : F911 - F918
[3] MECHANISM OF ATRIAL NATRIURETIC FACTOR-INDUCED INHIBITION OF RAT MESANGIAL CELL MITOGENESIS
APPEL, RG
[J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1990, 259 (03): : E312 - E318
[4] GROWTH INHIBITORY ACTIVITY OF ATRIAL NATRIURETIC FACTOR IN RAT GLOMERULAR MESANGIAL CELLS
APPEL, RG
[J]. FEBS LETTERS, 1988, 238 (01) : 135 - 138
[5] PHYSIOLOGICAL REGULATION OF ATRIAL-NATRIURETIC-PEPTIDE RECEPTORS IN RAT RENAL GLOMERULI
BALLERMANN, BJ
HOOVER, RL
KARNOVSKY, MJ
BRENNER, BM
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1985, 76 (06) : 2049 - 2056
[6] AUTORADIOGRAPHIC LOCALIZATION OF ATRIAL-NATRIURETIC-PEPTIDE RECEPTOR SUBTYPES IN RAT-KIDNEY
BROWN, J
SALAS, SP
SINGLETON, A
POLAK, JM
DOLLERY, CT
[J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1990, 259 (01): : F26 - F39
[7] CLEARANCE RECEPTOR-BINDING ATRIAL NATRIURETIC PEPTIDES INHIBIT MITOGENESIS AND PROLIFERATION OF RAT AORTIC SMOOTH-MUSCLE CELLS
CAHILL, PA
HASSID, A
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1991, 179 (03) : 1606 - 1613
[8] INHIBITION OF RAT MESANGIAL CELL MITOGENESIS BY NITRIC OXIDE-GENERATING VASODILATORS
GARG, UC
HASSID, A
[J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1989, 257 (01): : F60 - F66
[9] DUAL MECHANISM OF ANGIOTENSIN-II INHIBITS ANP-INDUCED MESANGIAL CGMP ACCUMULATION
HANEDA, M
KIKKAWA, R
MAEDA, S
TOGAWA, M
KOYA, D
HORIDE, N
KAJIWARA, N
SHIGETA, Y
[J]. KIDNEY INTERNATIONAL, 1991, 40 (02) : 188 - 194
[10] METABOLIC ACTIONS OF INSULIN-LIKE GROWTH FACTOR-I IN CULTURED GLOMERULAR MESANGIAL CELLS
HANEDA, M
KIKKAWA, R
TOGAWA, M
KOYA, D
KAJIWARA, N
SHIGETA, Y
[J]. METABOLISM-CLINICAL AND EXPERIMENTAL, 1991, 40 (12): : 1311 - 1316

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