THE BIOACTIVITY OF INSULIN ANALOGS FROM INVITRO RECEPTOR-BINDING TO INVIVO GLUCOSE-UPTAKE

[91] Lewis RE, Wu GP, MacDonald RG, Czech MP, Insulin‐sensitive phosphorylation of serine 1293/1294 on the human insulin receptor by a tightly associated serine kinase, J Biol Chem, 265, pp. 947-954, (1990)

[92] Drejer K, Kruse V, Larsen UD, Hougaard P, Bjorn S, Gammeltoft S, Receptor binding and tyrosine kinase activation by insulin analogues with extreme affinities studied in human hepatoma HepG2 cells, Diabetes, 40, pp. 1488-1495, (1991)

[93] Podskalny JM, Takeda S, Silverman RE, Tran D, Carpentier JL, Orci L, Gorden P, Insulin receptors and bioresponses in a human liver cell line (HepG2), Eur J Biochem, 150, pp. 401-407, (1985)

[94] Verspohl EJ, Roth RA, Vigneri R, Goldfine ID, Dual regulation of glycogen metabolism by insulin and insulin‐like growth factors in human hepatoma cells (HEP‐G2). Analysis with an anti‐receptor monoclonal antibody, J Clin Invest, 74, pp. 1436-1443, (1984)

[95] Keefer LM, Piron M-A, De Meyts P, Gattner HG, Diaconescu C, Saunders D, Brandenburg D, Impaired negative cooperativity of the semisynthetic analogues human [Leu^B24]‐ and [Leu^B25]‐ insulins, Biochem Biophys Res Commun, 100, pp. 1229-1236, (1981)

[96] Tager H, Thomas N, Assoian R, Rubenstein A, Saekow M, Olefsky J, Kaiser ET, Semisynthesis and biological activity of porcine (Leu^B24) insulin and (Leu^B25) insulin, Proc Natl Acad Sci USA, 77, pp. 3181-3185, (1980)

[97] Kobayashi M, Ohgaku S, Iwasaki M, Maegawa H, Watanabe N, Shigeta Y, Inouye K, Receptor binding and biological activity of supernormal insulin, [D‐Phe^B24]insulin, Current and Future Therapies with Insulin, pp. 136-141, (1983)

[98] Pullen RA, Lindsay DG, Wood SP, Tickle, Blundell TL, Wollmer A, Krail G, Brandenburg D, Zahn H, Glieman J, Gammeltoft S, Receptor‐binding region of insulin, Nature, 259, pp. 369-373, (1976)

[99] Hartmann H, Oberhaus K, Spahr R, Brandenburg D, Creutzfeldt W, Probst I, Biological activity of des‐(B26‐B30)‐insulinamide and related analogues in rat hepatocyte cultures, Diabetologia, 32, pp. 416-420, (1989)

[100] Schwartz GP, Burke GT, Katsoyannis PG, A superactive insulin: [B10‐aspartic acid]insulin (human), Proc Natl Acad Sci USA, 84, pp. 6408-6411, (1987)

[91] Lewis RE, Wu GP, MacDonald RG, Czech MP, Insulin‐sensitive phosphorylation of serine 1293/1294 on the human insulin receptor by a tightly associated serine kinase, J Biol Chem, 265, pp. 947-954, (1990)

[92] Drejer K, Kruse V, Larsen UD, Hougaard P, Bjorn S, Gammeltoft S, Receptor binding and tyrosine kinase activation by insulin analogues with extreme affinities studied in human hepatoma HepG2 cells, Diabetes, 40, pp. 1488-1495, (1991)

[93] Podskalny JM, Takeda S, Silverman RE, Tran D, Carpentier JL, Orci L, Gorden P, Insulin receptors and bioresponses in a human liver cell line (HepG2), Eur J Biochem, 150, pp. 401-407, (1985)

[94] Verspohl EJ, Roth RA, Vigneri R, Goldfine ID, Dual regulation of glycogen metabolism by insulin and insulin‐like growth factors in human hepatoma cells (HEP‐G2). Analysis with an anti‐receptor monoclonal antibody, J Clin Invest, 74, pp. 1436-1443, (1984)

[95] Keefer LM, Piron M-A, De Meyts P, Gattner HG, Diaconescu C, Saunders D, Brandenburg D, Impaired negative cooperativity of the semisynthetic analogues human [Leu^B24]‐ and [Leu^B25]‐ insulins, Biochem Biophys Res Commun, 100, pp. 1229-1236, (1981)

[96] Tager H, Thomas N, Assoian R, Rubenstein A, Saekow M, Olefsky J, Kaiser ET, Semisynthesis and biological activity of porcine (Leu^B24) insulin and (Leu^B25) insulin, Proc Natl Acad Sci USA, 77, pp. 3181-3185, (1980)

[97] Kobayashi M, Ohgaku S, Iwasaki M, Maegawa H, Watanabe N, Shigeta Y, Inouye K, Receptor binding and biological activity of supernormal insulin, [D‐Phe^B24]insulin, Current and Future Therapies with Insulin, pp. 136-141, (1983)

[98] Pullen RA, Lindsay DG, Wood SP, Tickle, Blundell TL, Wollmer A, Krail G, Brandenburg D, Zahn H, Glieman J, Gammeltoft S, Receptor‐binding region of insulin, Nature, 259, pp. 369-373, (1976)

[99] Hartmann H, Oberhaus K, Spahr R, Brandenburg D, Creutzfeldt W, Probst I, Biological activity of des‐(B26‐B30)‐insulinamide and related analogues in rat hepatocyte cultures, Diabetologia, 32, pp. 416-420, (1989)

[100] Schwartz GP, Burke GT, Katsoyannis PG, A superactive insulin: [B10‐aspartic acid]insulin (human), Proc Natl Acad Sci USA, 84, pp. 6408-6411, (1987)