BRIEF-LIFETIME, FAST-INACTIVATING ION CHANNELS ACCOUNT FOR THE ALPHA-BUNGAROTOXIN-SENSITIVE NICOTINIC RESPONSE IN HIPPOCAMPAL-NEURONS

被引：65

作者：

CASTRO, NG

ALBUQUERQUE, EX

机构：

[1] UNIV MARYLAND,SCH MED,DEPT PHARMACOL & EXPTL THERAPEUT,BALTIMORE,MD 21201

[2] FED UNIV RIO DE JANEIRO,INST BIOPHYS CARLOS CHAGAS FILHO,MOLEC PHARMACOL LAB 2,RIO JANEIRO,BRAZIL

来源：

NEUROSCIENCE LETTERS | 1993年 / 164卷 / 1-2期

关键词：

NICOTINIC RECEPTOR; HIPPOCAMPUS; ALPHA-BUNGAROTOXIN; ACETYLCHOLINE; METHYLLYCACONITINE; RAT; ION CHANNEL;

D O I：

10.1016/0304-3940(93)90876-M

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Single-channel currents underlying the various types of nicotinic receptor-gated whole-cell currents (previously termed IA, IB, II and III) were identified in rat hippocampal neurons. In response to applied acetylcholine (ACh), most of the neurons showed a fast-decaying whole-cell current (type IA) that can be blocked by alpha-bungarotoxin (alpha-BGT). In these neurons, a novel nicotinic receptor channel was found, having a conductance of 73 pS and an open time of 0.12 ms at -80 mV. This channel showed a fast concentration-dependent inactivation that had a time constant of 0.5 ms at 1 mM ACh. A high Ca2+ permeability and the involvement of alpha 7 receptor subunits in the channel structure were suggested.

引用

页码：137 / 140

页数：4

共 21 条

[11] FUNCTIONAL CONTRIBUTION OF NEURONAL ACHR SUBUNITS REVEALED BY ANTISENSE OLIGONUCLEOTIDES
LISTERUD, M
BRUSSAARD, AB
DEVAY, P
COLMAN, DR
ROLE, LW
[J]. SCIENCE, 1991, 254 (5037) : 1518 - 1521
[12] CONDUCTANCE AND KINETIC-PROPERTIES OF SINGLE NICOTINIC ACETYLCHOLINE-RECEPTOR CHANNELS IN RAT SYMPATHETIC NEURONS
MATHIE, A
CULLCANDY, SG
COLQUHOUN, D
[J]. JOURNAL OF PHYSIOLOGY-LONDON, 1991, 439 : 717 - 750
[13] SAMPLING, LOG BINNING, FITTING, AND PLOTTING DURATIONS OF OPEN-AND-SHUT INTERVALS FROM SINGLE CHANNELS AND THE EFFECTS OF NOISE
MCMANUS, OB
BLATZ, AL
MAGLEBY, KL
[J]. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1987, 410 (4-5): : 530 - 553
[14] MUTATIONS IN THE CHANNEL DOMAIN ALTER DESENSITIZATION OF A NEURONAL NICOTINIC RECEPTOR
REVAH, F
BERTRAND, D
GALZI, JL
DEVILLERSTHIERY, A
MULLE, C
HUSSY, N
BERTRAND, S
BALLIVET, M
CHANGEUX, JP
[J]. NATURE, 1991, 353 (6347) : 846 - 849
[15] Role L W, 1992, Curr Opin Neurobiol, V2, P254, DOI 10.1016/0959-4388(92)90112-X
[16] THE DIVERSITY OF NEURONAL NICOTINIC ACETYLCHOLINE-RECEPTORS
SARGENT, PB
[J]. ANNUAL REVIEW OF NEUROSCIENCE, 1993, 16 : 403 - 443
[17] BRAIN ALPHA-BUNGAROTOXIN BINDING-PROTEIN CDNAS AND MABS REVEAL SUBTYPES OF THIS BRANCH OF THE LIGAND-GATED ION CHANNEL GENE SUPERFAMILY
SCHOEPFER, R
CONROY, WG
WHITING, P
GORE, M
LINDSTROM, J
[J]. NEURON, 1990, 5 (01) : 35 - 48
[18] SEGUELA P, 1993, J NEUROSCI, V13, P596
[19] DATA TRANSFORMATIONS FOR IMPROVED DISPLAY AND FITTING OF SINGLE-CHANNEL DWELL TIME HISTOGRAMS
SIGWORTH, FJ
SINE, SM
[J]. BIOPHYSICAL JOURNAL, 1987, 52 (06) : 1047 - 1054
[20] NICOTINIC RECEPTORS THAT BIND ALPHA-BUNGAROTOXIN ON NEURONS RAISE INTRACELLULAR FREE CA2+
VIJAYARAGHAVAN, S
PUGH, PC
ZHANG, ZW
RATHOUZ, MM
BERG, DK
[J]. NEURON, 1992, 8 (02) : 353 - 362

← 1 2 3 →