THE RISK OF NITROGEN-DIOXIDE - WHAT HAVE WE LEARNED FROM EPIDEMIOLOGIC AND CLINICAL-STUDIES

被引：95

作者：

SAMET, JM ^{[1
]}

UTELL, MJ ^{[1
]}

机构：

[1] UNIV ROCHESTER,MED CTR,DEPT MED,PULM & CRIT CARE UNIT,ROCHESTER,NY 14642

来源：

TOXICOLOGY AND INDUSTRIAL HEALTH | 1990年 / 6卷 / 02期

关键词：

D O I：

10.1177/074823379000600204

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Nitrogen dioxide (NO2) is an oxidant gas which contaminates ambient air in many urban and industrial locations, and indoor air in homes with combustion appliances. The Environmental Protection Agency presently regulates NO2 in ambient air as a 'criteria' pollutant. In spite of decades of laboratory, clinical, and epidemiological research, the health effects of NO2 exposure on humans are not well understood. The toxicological evidence suggests that increased susceptibility to infection, functional deficits from effects on airways, and deterioration of the status of persons with chronic respiratory conditions, including asthmatics, are of potential concern. This paper provides a perspective on the present evidence related to human health effects of NO2. It addresses methodological barriers that limit the available data; assesses the adequacy of the data for risk assessment; and proposes a research agenda to obtain needed information on the health effects of NO2.

引用

页码：247 / 262

页数：16

共 56 条

[31]

MUSTAFA MG, 1978, AM REV RESPIR DIS, V118, P1061

[32] EFFECT OF SHORT-TERM, LOW-LEVEL NITROGEN-DIOXIDE EXPOSURE ON BRONCHIAL SENSITIVITY OF ASTHMATIC-PATIENTS [J].

OREHEK, J ;

MASSARI, JP ;

GAYRARD, P ;

GRIMAUD, C ;

CHARPIN, J .

JOURNAL OF CLINICAL INVESTIGATION, 1976, 57 (02) :301-307

[33]

Overton J. H., 1988, AIR POLLUTION AUTOMO, P367

[34]

OZKAYNAK H, 1984, 1984 AIR POLL CONTR

[35]

PENNINGTON JE, 1988, AIR POLLUTION AUTOMO, P499

[36]

PICKRELL J A, 1981, Chest, V80, p50S, DOI 10.1378/chest.80.1_Supplement.50S

[37]

ROGER LJ, 1985, TOXICOLOGIST, V5, P70

[38]

ROGER LJ, 1986, TOXICOLOGIST, V6, P31

[39] THE PATHO-PHYSIOLOGY OF ENHANCED SUSCEPTIBILITY TO MURINE CYTOMEGALO-VIRUS RESPIRATORY-INFECTION DURING SHORT-TERM EXPOSURE TO 5-PPM NITROGEN-DIOXIDE [J].

ROSE, RM ;

FUGLESTAD, JM ;

SKORNIK, WA ;

HAMMER, SM ;

WOLFTHAL, SF ;

BECK, BD ;

BRAIN, JD .

AMERICAN REVIEW OF RESPIRATORY DISEASE, 1988, 137 (04) :912-917

[40] HEALTH-EFFECTS AND SOURCES OF INDOOR AIR-POLLUTION .1. [J].

SAMET, JM ;

MARBURY, MC ;

SPENGLER, JD .

AMERICAN REVIEW OF RESPIRATORY DISEASE, 1987, 136 (06) :1486-1508

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