P2-PEPTIDE INDUCED EXPERIMENTAL ALLERGIC NEURITIS - A MODEL TO STUDY AXONAL DEGENERATION

被引：51

作者：

HAHN, AF

FEASBY, TE

WILKIE, L

LOVGREN, D

机构：

[1] Department of Clinical Neurological Sciences, University of Western Ontario, Victoria Hospital, London, N6A 4G5, Ontario

来源：

ACTA NEUROPATHOLOGICA | 1991年 / 82卷 / 01期

关键词：

EXPERIMENTAL ALLERGIC NEURITIS; P2 MYELIN PEPTIDE; DEMYELINATION; AXONAL DEGENERATION; EXPERIMENTAL AUTOIMMUNE NEURITIS; PERIPHERAL NERVOUS-SYSTEM; BOVINE P-2 PROTEIN; WALLERIAN DEGENERATION; MYELIN PHAGOCYTOSIS; SCHWANN-CELLS; MACROPHAGES; IDENTIFICATION; PATHOGENESIS;

D O I：

10.1007/BF00310924

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In experimental allergic neuritis (EAN) severity of clinical disease and pathology correlate with the dose of antigen (Hahn et al., Lab Invest 59:115-125, 1988). To avoid axonal membrane contamination of the antigen, EAN was induced with a synthetic peptide, corresponding to residues 53-78 of bovine P2 myelin protein. Severity of EAN correlated with the dose of peptide in the inoculate. The relationship between demyelination, inflammation and axonal degeneration was studied. Low doses resulted in pure demyelination. Axonal degeneration occurred only with high doses of antigen and in association with very active mononuclear inflammation. The role of macrophages in producing axonal damage is discussed.

引用

页码：60 / 65

页数：6

共 34 条

[21] AXONAL DEGENERATION IN DEMYELINATING DISORDERS [J].

MADRID, RE ;

WISNIEWSKI, HM .

JOURNAL OF NEUROCYTOLOGY, 1977, 6 (01) :103-117

[22] NEW MINIMUM LENGTH REQUIREMENT FOR A T-CELL EPITOPE FOR EXPERIMENTAL ALLERGIC NEURITIS [J].

OLEE, T ;

POWELL, HC ;

BROSTOFF, SW .

JOURNAL OF NEUROIMMUNOLOGY, 1990, 27 (2-3) :187-190

[23]

PRINEAS JW, 1972, LAB INVEST, V26, P133

[24] SEVERE ACUTE GUILLAIN-BARRE-SYNDROME [J].

ROPPER, AH .

NEUROLOGY, 1986, 36 (03) :429-432

[25] THE ROLE OF MYELIN-P2 PROTEIN IN THE PRODUCTION OF EXPERIMENTAL ALLERGIC NEURITIS [J].

ROSTAMI, A ;

BROWN, MJ ;

LISAK, RP ;

SUMNER, AJ ;

ZWEIMAN, B ;

PLEASURE, DE .

ANNALS OF NEUROLOGY, 1984, 16 (06) :680-685

[26]

ROSTAMI A M, 1988, Neurology, V38, P375

[27] P2 PROTEIN-INDUCED EXPERIMENTAL ALLERGIC NEURITIS - AN ULTRASTRUCTURAL-STUDY [J].

SAIDA, K ;

SAIDA, T ;

PLEASURE, DE ;

NISHITANI, H .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 1983, 62 (1-3) :77-93

[28] MYELIN PHAGOCYTOSIS IN WALLERIAN DEGENERATION - PROPERTIES OF MILLIPORE DIFFUSION-CHAMBERS AND IMMUNOHISTOCHEMICAL IDENTIFICATION OF CELL-POPULATIONS [J].

SCHEIDT, P ;

FRIEDE, RL .

ACTA NEUROPATHOLOGICA, 1987, 75 (01) :77-84

[29] MACROPHAGES BUT NOT SCHWANN-CELLS EXPRESS IA-ANTIGEN IN EXPERIMENTAL AUTOIMMUNE NEURITIS [J].

SCHMIDT, B ;

STOLL, G ;

HARTUNG, HP ;

HEININGER, K ;

SCHAFER, B ;

TOYKA, KV .

ANNALS OF NEUROLOGY, 1990, 28 (01) :70-77

[30] ULTRASTRUCTURE OF EXPERIMENTAL ALLERGIC NEURITIS IN RABBIT [J].

SCHRODER, JM .

ACTA NEUROPATHOLOGICA, 1970, 14 (04) :261-&

← 1 2 3 4 →