ENZYMES IN ORGANIC-SYNTHESIS .20. SYNTHESIS OF (3R,5S)-3-HYDROXY-7-PHENYL-6-HEPTYN-5-OLIDE BY AN ENANTIOSELECTIVE ENZYME-CATALYZED LACTONIZATION OF A RACEMIC 3,5-DIHYDROXY ESTER

被引：12

作者：

HENKEL, B ^{[1
]}

KUNATH, A ^{[1
]}

SCHICK, H ^{[1
]}

机构：

[1] CTR SELECT ORGAN SYNTH,D-12489 BERLIN,GERMANY

来源：

TETRAHEDRON-ASYMMETRY | 1994年 / 5卷 / 01期

关键词：

D O I：

10.1016/S0957-4166(00)80473-5

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

(3R,5S)-3-Hydroxy-7-phenyl-6-heptyn-5-olide was obtained with a high enantiomeric excess by an enzyme-catalyzed enantioselective lactonization of the corresponding methyl(3R*,5S*)-dihydroxyalkynoate followed by spontaneous crystallization.

引用

页码：17 / 18

页数：2

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