TRANSFORMING GROWTH-FACTOR-BETA POTENTIATES EPIDERMAL GROWTH FACTOR-INDUCED PROSTAGLANDIN-E2 PRODUCTION IN AMNION CELLS

被引：12

作者：

KNISS, DA ^{[1
]}

ZIMMERMAN, PD ^{[1
]}

FERTEL, RH ^{[1
]}

IAMS, JD ^{[1
]}

机构：

[1] OHIO STATE UNIV,COLL MED,DEPT PHARMACOL,COLUMBUS,OH 43210

来源：

PROSTAGLANDINS | 1993年 / 45卷 / 01期

关键词：

D O I：

10.1016/0090-6980(93)90087-N

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Primary cultures of human amnion cells and the amnion-derived cell line WISH were used to evaluate the hypothesis that transforming growth factor-beta (TGF-beta) can modulate epidermal growth factor (EGF)- induced prostaglandin E2 (PGE2) production. Cells were preincubated for 1 hr with TGF-beta (0.0001-10 ng/ml) and then incubated in the presence or absence of EGF (10 ng/ml) for 4 hrs. TGF-beta alone did not stimulate PGE, synthesis at any dose examined. However, when primary cultures of amnion cells or WISH cells were preincubated with TGF-beta and then challenged with EGF, there was a potentiation of PGE, production that was much greater than the additive values of TGF-beta or EGF alone. These data suggest that EGF-induced PGE2 production by amnion cells can be modulated by low concentrations of TGF-beta.

引用

页码：27 / 33

页数：7

共 27 条

[21] OKITA JR, 1983, IN VITRO CELL DEV B, V19, P117
[22] TRANSFORMING GROWTH FACTOR-BETA-2 DIFFERENTIALLY MODULATES INTERLEUKIN-1-BETA-STIMULATED AND TUMOR-NECROSIS-FACTOR-ALPHA-STIMULATED PHOSPHOLIPASE-A2 AND PROSTAGLANDIN-E2 SYNTHESIS IN RAT RENAL MESANGIAL CELLS
PFEILSCHIFTER, J
PIGNAT, W
LEIGHTON, J
MARKI, F
VOSBECK, K
ALKAN, S
[J]. BIOCHEMICAL JOURNAL, 1990, 270 (01) : 269 - 271
[23] BINDING-SITES FOR EPIDERMAL GROWTH-FACTOR IN HUMAN-FETAL MEMBRANES
RAO, CV
CARMAN, FR
CHEGINI, N
SCHULTZ, GS
[J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1984, 58 (06) : 1034 - 1042
[24] PROSTAGLANDIN CONCENTRATIONS IN AMNIOTIC-FLUID OF WOMEN WITH INTRAAMNIOTIC INFECTION AND PRETERM LABOR
ROMERO, R
EMAMIAN, M
WAN, M
QUINTERO, R
HOBBINS, JC
MITCHELL, MD
[J]. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1987, 157 (06) : 1461 - 1467
[25] INITIATION OF HUMAN PARTURITION .2. IDENTIFICATION OF PHOSPHOLIPASE-A2 IN FETAL CHORIOAMNION AND UTERINE DECIDUA
SCHULTZ, FM
SCHWARZ, BE
MACDONALD, PC
JOHNSTON, JM
[J]. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1975, 123 (06) : 650 - 653
[26] CATECHOLAMINES MODULATE EPIDERMAL GROWTH-FACTOR INDUCED PROSTAGLANDIN-E2 PRODUCTION IN AMNION-LIKE (WISH) CELLS BY MEANS OF A CYCLIC ADENOSINE-MONOPHOSPHATE DEPENDENT PATHWAY
SU, HC
FERTEL, RH
KNISS, DA
[J]. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1992, 166 (01) : 236 - 241
[27] INFLAMMATORY AND IMMUNOMODULATORY ROLES OF TGF-BETA
WAHL, SM
MCCARTNEYFRANCIS, N
MERGENHAGEN, SE
[J]. IMMUNOLOGY TODAY, 1989, 10 (08): : 258 - 261

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