EVAPORATIVE LIGHT-SCATTERING AND THERMOSPRAY MASS-SPECTROMETRY - 2 ALTERNATIVE METHODS FOR DETECTION AND QUANTITATIVE LIQUID-CHROMATOGRAPHIC DETERMINATION OF GINKGOLIDES AND BILOBALIDE IN GINKGO-BILOBA LEAF EXTRACTS AND PHYTOPHARMACEUTICALS

被引：41

作者：

CAMPONOVO, FF ^{[1
]}

WOLFENDER, JL ^{[1
]}

MAILLARD, MP ^{[1
]}

POTTERAT, O ^{[1
]}

HOSTETTMANN, K ^{[1
]}

机构：

[1] UNIV LAUSANNE,ECOLE PHARM,INST PHARMACOGNOISE & PHYTOCHIM,CH-1015 LAUSANNE,SWITZERLAND

来源：

PHYTOCHEMICAL ANALYSIS | 1995年 / 6卷 / 03期

关键词：

GINKGOLIDES A; B; C; J; BILOBALIDE; GINKGO-BILOBA; LIQUID CHROMATOGRAPHY - THERMOSPRAY - MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY - EVAPORATIVE LIGHT SCATTERING DETECTION; GAS CHROMATOGRAPHY - FLAME IONIZATION DETECTION;

D O I：

10.1002/pca.2800060306

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Evaporative light scattering and thermospray mass spectrometry have been investigated as two alternative methods for the liquid chromatographic detection of ginkgolides and bilobalide. Both techniques were used to quantify these metabolites in leaf extracts and in some phytopharmaceuticals. Only a minimum of sample prepurification was required. Results were compared with those obtained by gas chromatography (flame ionization detection), which is one of most suitable methods for routine determinations of such compounds. The isolation of ginkgolides A, B, C, and J and bilobalide from leaves of Ginkgo biloba is also described.

引用

页码：141 / 148

页数：8

共 24 条

[11] ONTOGENIC ASPECTS OF GINKGOLIDE PRODUCTION IN GINKGO-BILOBA [J].

HUH, H ;

STABA, EJ .

PLANTA MEDICA, 1993, 59 (03) :232-239

[12]

KOMODA Y, 1988, IYO KIZAI KENKYUSHO, V22, P83

[13] ANALYSIS OF TERPENES FROM GINKGO-BILOBA L BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY [J].

LOBSTEINGUTH, A ;

BRIANCONSCHEID, F ;

ANTON, R .

JOURNAL OF CHROMATOGRAPHY, 1983, 267 (02) :431-438

[14] USE OF LIQUID-CHROMATOGRAPHY THERMOSPRAY MASS-SPECTROMETRY IN PHYTOCHEMICAL ANALYSIS OF CRUDE PLANT-EXTRACTS [J].

MAILLARD, MP ;

WOLFENDER, JL ;

HOSTETTMANN, K .

JOURNAL OF CHROMATOGRAPHY, 1993, 647 (01) :147-154

[15]

MILLER JC, 1984, STATISTICS ANAL CHEM

[16]

NIESSEN WMA, 1992, CHROMATOGR SCI SER, V58

[17]

OBERPICHLERSCHW.H, 1992, PHARM UNSERER Z, V21, P2124

[18] RAPID LIQUID-CHROMATOGRAPHY OF TERPENES IN GINKGO-BILOBA L EXTRACTS AND PRODUCTS [J].

PIETTA, P ;

MAURI, P ;

RAVA, A .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 1992, 10 (10-12) :1077-1079

[19] ANALYSIS OF TERPENES FROM GINKGO-BILOBA L EXTRACTS BY REVERSED PHASE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY [J].

PIETTA, PG ;

MAURI, PL ;

RAVA, A .

CHROMATOGRAPHIA, 1990, 29 (5-6) :251-253

[20] BIOLOGICAL STANDARDIZATION OF GINKGO EXTRACTS [J].

STEINKE, B ;

MULLER, B ;

WAGNER, H .

PLANTA MEDICA, 1993, 59 (02) :155-160

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